In mouse V1, the behavioral effect of holographically activating a small ensemb…

In mouse V1, the behavioral effect of holographically activating a small ensemble is best predicted by the ensemble's recurrent network influence (effect on local activity), not by the visual selectivity of the activated cells — direct causal evidence that recurrent E→E network coupling, not feedforward labels, governs perceptual readout.

{
  "n": 0,
  "doi": "10.1016/j.neuron.2025.04.023",
  "claim": "In mouse V1, the behavioral effect of holographically activating a small ensemble is best predicted by the ensemble's recurrent network influence (effect on local activity), not by the visual selectivity of the activated cells — direct causal evidence that recurrent E→E network coupling, not feedforward labels, governs perceptual readout.",
  "cite_key": "Bounds2025",
  "evidence": "Two-photon imaging combined with cellular-resolution holographic optogenetic photostimulation in awake mice performing a visual detection task; ensembles selected by visual selectivity vs randomly.",
  "effect_size": "targeted activation of visually sensitive ensembles did NOT preferentially modify behavior versus random ensembles (qualitative)",
  "text_access": "abstract_only",
  "study_system": "Mouse V1, awake behaving; 2P holographic optogenetics + imaging + detection task",
  "argument_role": "supporting",
  "replication_status": "within_lab",
  "claim_source_sentence": "Instead, an activated ensemble's effect on local network activity was the main predictor of its impact on perception.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Contrary to expectations, targeted activation of visually sensitive neural ensembles did not preferentially modify behavior compared with targeting randomly selected ensembles."
}

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