Version history

{
  "scope": "Mouse V1; AM-251 layer-targeted pharmacology; OD-plasticity readout in L2/3 and L5",
  "claim_text": "In mouse V1, blocking ocular-dominance plasticity in layer 2/3 with AM-251 does not impair plasticity in layer 5, indicating that L5 plasticity is not strictly downstream of L2/3 within the canonical L4→L2/3→L5 microcircuit.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.cub.2020.05.067",
    "claim": "In mouse V1, blocking ocular-dominance plasticity in layer 2/3 with AM-251 does not impair plasticity in layer 5, indicating that L5 plasticity is not strictly downstream of L2/3 within the canonical L4→L2/3→L5 microcircuit.",
    "cite_key": "Frantz2020",
    "evidence": "Layer-targeted pharmacology (AM-251) in mouse V1 with measurement of OD plasticity in L2/3 vs L5.",
    "effect_size": "L5 OD plasticity preserved when L2/3 plasticity blocked.",
    "text_access": "abstract_only",
    "study_system": "Mouse V1; AM-251 layer-targeted pharmacology; OD-plasticity readout in L2/3 and L5",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "Interestingly, blocking OD plasticity in L2/3 with the drug AM-251 did not impair OD plasticity in L5.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "L5 OD plasticity preserved when L2/3 plasticity blocked.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-c4c760105083"
  ],
  "source_span": "Interestingly, blocking OD plasticity in L2/3 with the drug AM-251 did not impair OD plasticity in L5.",
  "study_system": "Mouse V1; AM-251 layer-targeted pharmacology; OD-plasticity readout in L2/3 and L5",
  "evidence_refs": [
    {
      "ref": "paper:paper-c4c760105083"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Layer-targeted pharmacology (AM-251) in mouse V1 with measurement of OD plasticity in L2/3 vs L5.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}