In mouse V1, blocking ocular-dominance plasticity in layer 2/3 with AM-251 does…

Details

scope: Mouse V1; AM-251 layer-targeted pharmacology; OD-plasticity readout in L2/3 and L5
claim_text: In mouse V1, blocking ocular-dominance plasticity in layer 2/3 with AM-251 does not impair plasticity in layer 5, indicating that L5 plasticity is not strictly downstream of L2/3 within the canonical L4→L2/3→L5 microcircuit.
section_id: section_04
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json
effect_size: L5 OD plasticity preserved when L2/3 plasticity blocked.
review_repo: ComputationalReviewRecurrence
section_ref: wiki_page:computationalreviewrecurrence-04-translaminar
source_kind: review_finding
source_path: evidence/section_04_evidence_package.json
source_span: Interestingly, blocking OD plasticity in L2/3 with the drug AM-251 did not impair OD plasticity in L5.
study_system: Mouse V1; AM-251 layer-targeted pharmacology; OD-plasticity readout in L2/3 and L5
section_title: 4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections
evidence_summary: Layer-targeted pharmacology (AM-251) in mouse V1 with measurement of OD plasticity in L2/3 vs L5.
review_bundle_ref: analysis_bundle:ab-d9c479db9be9
replication_status: single_study
review_package_ref: analysis_bundle:ab-d9c479db9be9
source_artifact_ref: wiki_page:computationalreviewrecurrence-04-translaminar
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json
commit_sha: 79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1016/j.cub.2020.05.067",
  "claim": "In mouse V1, blocking ocular-dominance plasticity in layer 2/3 with AM-251 does not impair plasticity in layer 5, indicating that L5 plasticity is not strictly downstream of L2/3 within the canonical L4→L2/3→L5 microcircuit.",
  "cite_key": "Frantz2020",
  "evidence": "Layer-targeted pharmacology (AM-251) in mouse V1 with measurement of OD plasticity in L2/3 vs L5.",
  "effect_size": "L5 OD plasticity preserved when L2/3 plasticity blocked.",
  "text_access": "abstract_only",
  "study_system": "Mouse V1; AM-251 layer-targeted pharmacology; OD-plasticity readout in L2/3 and L5",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Interestingly, blocking OD plasticity in L2/3 with the drug AM-251 did not impair OD plasticity in L5.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-c4c760105083"
]

evidence_refs

[
  {
    "ref": "paper:paper-c4c760105083"
  }
]

source_policy

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In mouse V1, blocking ocular-dominance plasticity in layer 2/3 with AM-251 does…

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