Version history

{
  "scope": "embryonic mouse LGE / SVZ / RMS / olfactory bulb",
  "claim_text": "Dlx1/2 are central and essential components of the transcriptional code generating olfactory-bulb (OB) interneurons: in Dlx1/2 constitutive null mutants, GSX2+/ASCL1+ neural progenitor differentiation, intermediate progenitor proliferation, and migration of immature OB interneurons through the rostral migratory stream are all impaired. Dlx1/2 act both upstream and parallel to other lineage TFs (Sp8, Sp9, Pax6) in the LGE → OB-IN trajectory.",
  "raw_fields": {
    "n": null,
    "doi": "10.1093/cercor/bhz018",
    "claim": "Dlx1/2 are central and essential components of the transcriptional code generating olfactory-bulb (OB) interneurons: in Dlx1/2 constitutive null mutants, GSX2+/ASCL1+ neural progenitor differentiation, intermediate progenitor proliferation, and migration of immature OB interneurons through the rostral migratory stream are all impaired. Dlx1/2 act both upstream and parallel to other lineage TFs (Sp8, Sp9, Pax6) in the LGE → OB-IN trajectory.",
    "title": null,
    "cite_key": "Guo2019b",
    "evidence": "Cerebral Cortex 2019. Method: Dlx1/2 mouse mutants; IHC/ISH tracing of GSX2/ASCL1/Sp8/Sp9 expression.",
    "effect_size": null,
    "figure_data": null,
    "text_access": "abstract_only",
    "key_entities": [
      "Dlx1",
      "Dlx2",
      "Sp8",
      "Sp9",
      "ASCL1",
      "GSX2",
      "Pax6",
      "LGE",
      "RMS",
      "olfactory bulb",
      "interneuron",
      "specification"
    ],
    "study_system": "embryonic mouse LGE / SVZ / RMS / olfactory bulb",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "single_study",
    "_source_cluster_index": 138,
    "claim_source_sentence": "Generation of olfactory bulb (OB) interneurons requires neural stem/progenitor cell specification, proliferation, differentiation, and young interneuron migration and maturation. Here, we show that the homeobox transcription factors Dlx1/2 are central and essential components in the transcriptional code for generating OB interneurons. In Dlx1/2 constitutive null mutants, the differentiation of GSX2+ and ASCL1+ neural stem/progenitor cells in the LGE is altered.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-002ab97ac82c"
  ],
  "source_span": "Generation of olfactory bulb (OB) interneurons requires neural stem/progenitor cell specification, proliferation, differentiation, and young interneuron migration and maturation. Here, we show that the homeobox transcription factors Dlx1/2 are central and essential components in the transcriptional code for generating OB interneurons. In Dlx1/2 constitutive null mutants, the differentiation of GSX2+ and ASCL1+ neura...",
  "study_system": "embryonic mouse LGE / SVZ / RMS / olfactory bulb",
  "evidence_refs": [
    {
      "ref": "paper:paper-002ab97ac82c"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Cerebral Cortex 2019. Method: Dlx1/2 mouse mutants; IHC/ISH tracing of GSX2/ASCL1/Sp8/Sp9 expression.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}