Dlx1/2 are central and essential components of the transcriptional code generat…

Dlx1/2 are central and essential components of the transcriptional code generating olfactory-bulb (OB) interneurons: in Dlx1/2 constitutive null mutants, GSX2+/ASCL1+ neural progenitor differentiation, intermediate progenitor proliferation, and migration of immature OB interneurons through the rostral migratory stream are all impaired. Dlx1/2 act both upstream and parallel to other lineage TFs (Sp8, Sp9, Pax6) in the LGE → OB-IN trajectory.

{
  "n": null,
  "doi": "10.1093/cercor/bhz018",
  "claim": "Dlx1/2 are central and essential components of the transcriptional code generating olfactory-bulb (OB) interneurons: in Dlx1/2 constitutive null mutants, GSX2+/ASCL1+ neural progenitor differentiation, intermediate progenitor proliferation, and migration of immature OB interneurons through the rostral migratory stream are all impaired. Dlx1/2 act both upstream and parallel to other lineage TFs (Sp8, Sp9, Pax6) in the LGE → OB-IN trajectory.",
  "title": null,
  "cite_key": "Guo2019b",
  "evidence": "Cerebral Cortex 2019. Method: Dlx1/2 mouse mutants; IHC/ISH tracing of GSX2/ASCL1/Sp8/Sp9 expression.",
  "effect_size": null,
  "figure_data": null,
  "text_access": "abstract_only",
  "key_entities": [
    "Dlx1",
    "Dlx2",
    "Sp8",
    "Sp9",
    "ASCL1",
    "GSX2",
    "Pax6",
    "LGE",
    "RMS",
    "olfactory bulb",
    "interneuron",
    "specification"
  ],
  "study_system": "embryonic mouse LGE / SVZ / RMS / olfactory bulb",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "single_study",
  "_source_cluster_index": 138,
  "claim_source_sentence": "Generation of olfactory bulb (OB) interneurons requires neural stem/progenitor cell specification, proliferation, differentiation, and young interneuron migration and maturation. Here, we show that the homeobox transcription factors Dlx1/2 are central and essential components in the transcriptional code for generating OB interneurons. In Dlx1/2 constitutive null mutants, the differentiation of GSX2+ and ASCL1+ neural stem/progenitor cells in the LGE is altered.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-002ab97ac82c"
]

Generation of olfactory bulb (OB) interneurons requires neural stem/progenitor cell specification, proliferation, differentiation, and young interneuron migration and maturation. Here, we show that the homeobox transcription factors Dlx1/2 are central and essential components in the transcriptional code for generating OB interneurons. In Dlx1/2 constitutive null mutants, the differentiation of GSX2+ and ASCL1+ neura...

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