Version history

{
  "scope": "Human postmortem brain, bipolar affective disorder",
  "claim_text": "Meta-analytical evidence supports PV interneuron loss or dysfunction in bipolar disorder, with a bidirectional relationship between mitochondrial energy deficiency and PV interneuron abnormalities.",
  "raw_fields": {
    "n": 0,
    "doi": "10.3389/fphar.2021.689473",
    "claim": "Meta-analytical evidence supports PV interneuron loss or dysfunction in bipolar disorder, with a bidirectional relationship between mitochondrial energy deficiency and PV interneuron abnormalities.",
    "evidence": "Meta-analytical evidence supports PV interneuron loss or dysfunction in bipolar disorder, with a bidirectional relationship between mitochondrial energy deficiency and PV interneuron abnormalities.",
    "effect_size": "Meta-analytical evidence of PV loss in BPAD",
    "text_access": "fulltext",
    "study_system": "Human postmortem brain, bipolar affective disorder",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "We hereby report meta-analytical evidence of parvalbumin interneurons loss or dysfunction in the brain of patients with Bipolar Affective Disorder (BPAD), a condition primarily characterized by mood instability for which the pathophysiological role of mitochondrial dysfunction has recently emerged as critically important.",
    "replication_evidence_dois": [
      "10.1007/s00702-019-02080-2"
    ],
    "effect_size_source_sentence": "We hereby report meta-analytical evidence of parvalbumin interneurons loss or dysfunction in the brain of patients with Bipolar Affective Disorder (BPAD)."
  },
  "section_id": "section_13_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_13_evidence_package.json",
  "effect_size": "Meta-analytical evidence of PV loss in BPAD",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-13",
  "source_kind": "review_finding",
  "source_path": "evidence/section_13_evidence_package.json",
  "source_refs": [
    "paper:paper-7c8238b53305"
  ],
  "source_span": "We hereby report meta-analytical evidence of parvalbumin interneurons loss or dysfunction in the brain of patients with Bipolar Affective Disorder (BPAD), a condition primarily characterized by mood instability for which the pathophysiological role of mitochondrial dysfunction has recently emerged as critically important.",
  "study_system": "Human postmortem brain, bipolar affective disorder",
  "evidence_refs": [
    {
      "ref": "paper:paper-7c8238b53305"
    }
  ],
  "section_title": "Cross-Cluster Synthesis: What Replicates, What Is Contested, What Is Untested",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Meta-analytical evidence supports PV interneuron loss or dysfunction in bipolar disorder, with a bidirectional relationship between mitochondrial energy deficiency and PV interneuron abnormalities.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-13",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_13_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}