- raw_fields
{
"n": 0,
"doi": "10.3389/fphar.2021.689473",
"claim": "Meta-analytical evidence supports PV interneuron loss or dysfunction in bipolar disorder, with a bidirectional relationship between mitochondrial energy deficiency and PV interneuron abnormalities.",
"evidence": "Meta-analytical evidence supports PV interneuron loss or dysfunction in bipolar disorder, with a bidirectional relationship between mitochondrial energy deficiency and PV interneuron abnormalities.",
"effect_size": "Meta-analytical evidence of PV loss in BPAD",
"text_access": "fulltext",
"study_system": "Human postmortem brain, bipolar affective disorder",
"replication_status": "independently_replicated",
"claim_source_sentence": "We hereby report meta-analytical evidence of parvalbumin interneurons loss or dysfunction in the brain of patients with Bipolar Affective Disorder (BPAD), a condition primarily characterized by mood instability for which the pathophysiological role of mitochondrial dysfunction has recently emerged as critically important.",
"replication_evidence_dois": [
"10.1007/s00702-019-02080-2"
],
"effect_size_source_sentence": "We hereby report meta-analytical evidence of parvalbumin interneurons loss or dysfunction in the brain of patients with Bipolar Affective Disorder (BPAD)."
}- source_refs
[
"paper:paper-7c8238b53305"
]
- source_span
We hereby report meta-analytical evidence of parvalbumin interneurons loss or dysfunction in the brain of patients with Bipolar Affective Disorder (BPAD), a condition primarily characterized by mood instability for which the pathophysiological role of mitochondrial dysfunction has recently emerged as critically important.
- evidence_refs
[
{
"ref": "paper:paper-7c8238b53305"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}