Version history

{
  "scope": "naturally sleeping male mice, layer 2/3 cortex, two-photon Ca2+ imaging",
  "claim_text": "Cortical layer 2/3 VIP interneurons display a ~0.02-Hz infraslow oscillation that is inversely phase-coupled to infraslow spindle activity during slow-wave sleep, a coupling absent in PV and SST interneurons.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.celrep.2025.116669",
    "pmid": "41385367",
    "year": "2025",
    "claim": "Cortical layer 2/3 VIP interneurons display a ~0.02-Hz infraslow oscillation that is inversely phase-coupled to infraslow spindle activity during slow-wave sleep, a coupling absent in PV and SST interneurons.",
    "pmcid": "",
    "title": "VIP interneuron activity during sleep conveys the cortical infraslow oscillation.",
    "authors": "",
    "journal": "",
    "cite_key": "Rolle2025",
    "evidence": "In vivo two-photon Ca2+ imaging of layer 2/3 VIP, PV, SST interneurons in naturally sleeping mice across wake/SWS/REM and during spindles/slow oscillations.",
    "cluster_id": "cluster_09_oscillations",
    "effect_size": "~0.02-Hz infraslow VIP rhythm; VIP activity acutely upregulated during spindles/SOs, lowest during SWS overall",
    "figure_data": [],
    "text_access": "abstract_only",
    "study_system": "naturally sleeping male mice, layer 2/3 cortex, two-photon Ca2+ imaging",
    "cited_by_count": 0,
    "_source_cluster": "cluster_09_oscillations",
    "replication_status": "single-study",
    "_source_cluster_index": 1,
    "claim_source_sentence": "Notably, across all states, VIP activity showed a profound ∼0.02-Hz infraslow rhythm, which, during SWS epochs, was inversely phase-coupled to the infraslow rhythm of spindle activity. In contrast, such coupling was absent in SST and PV interneurons, suggesting that VIP cells uniquely regulate infraslow spindle-related dynamics within cortical circuits.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "VIP activity was lowest during SWS and acutely upregulated during spindles and SOs, presumably facilitating memory processing in cortical circuits."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "~0.02-Hz infraslow VIP rhythm; VIP activity acutely upregulated during spindles/SOs, lowest during SWS overall",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-a9dfac627c9e"
  ],
  "source_span": "Notably, across all states, VIP activity showed a profound ∼0.02-Hz infraslow rhythm, which, during SWS epochs, was inversely phase-coupled to the infraslow rhythm of spindle activity. In contrast, such coupling was absent in SST and PV interneurons, suggesting that VIP cells uniquely regulate infraslow spindle-related dynamics within cortical circuits.",
  "study_system": "naturally sleeping male mice, layer 2/3 cortex, two-photon Ca2+ imaging",
  "evidence_refs": [
    {
      "ref": "paper:paper-a9dfac627c9e"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "In vivo two-photon Ca2+ imaging of layer 2/3 VIP, PV, SST interneurons in naturally sleeping mice across wake/SWS/REM and during spindles/slow oscillations.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}