Cortical layer 2/3 VIP interneurons display a ~0.02-Hz infraslow oscillation th…

{
  "n": null,
  "doi": "10.1016/j.celrep.2025.116669",
  "pmid": "41385367",
  "year": "2025",
  "claim": "Cortical layer 2/3 VIP interneurons display a ~0.02-Hz infraslow oscillation that is inversely phase-coupled to infraslow spindle activity during slow-wave sleep, a coupling absent in PV and SST interneurons.",
  "pmcid": "",
  "title": "VIP interneuron activity during sleep conveys the cortical infraslow oscillation.",
  "authors": "",
  "journal": "",
  "cite_key": "Rolle2025",
  "evidence": "In vivo two-photon Ca2+ imaging of layer 2/3 VIP, PV, SST interneurons in naturally sleeping mice across wake/SWS/REM and during spindles/slow oscillations.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "~0.02-Hz infraslow VIP rhythm; VIP activity acutely upregulated during spindles/SOs, lowest during SWS overall",
  "figure_data": [],
  "text_access": "abstract_only",
  "study_system": "naturally sleeping male mice, layer 2/3 cortex, two-photon Ca2+ imaging",
  "cited_by_count": 0,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "single-study",
  "_source_cluster_index": 1,
  "claim_source_sentence": "Notably, across all states, VIP activity showed a profound ∼0.02-Hz infraslow rhythm, which, during SWS epochs, was inversely phase-coupled to the infraslow rhythm of spindle activity. In contrast, such coupling was absent in SST and PV interneurons, suggesting that VIP cells uniquely regulate infraslow spindle-related dynamics within cortical circuits.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "VIP activity was lowest during SWS and acutely upregulated during spindles and SOs, presumably facilitating memory processing in cortical circuits."
}

[
  "paper:paper-a9dfac627c9e"
]

Notably, across all states, VIP activity showed a profound ∼0.02-Hz infraslow rhythm, which, during SWS epochs, was inversely phase-coupled to the infraslow rhythm of spindle activity. In contrast, such coupling was absent in SST and PV interneurons, suggesting that VIP cells uniquely regulate infraslow spindle-related dynamics within cortical circuits.

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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