High-resolution mesoscale mapping in mouse delineates six parallel cortico–basa…

{
  "n": 0,
  "doi": "10.1038/s41586-021-03993-3",
  "claim": "High-resolution mesoscale mapping in mouse delineates six parallel cortico–basal ganglia–thalamic subnetworks, each closing back onto its originating corticostriatal neurons.",
  "cite_key": "Foster2021",
  "evidence": "Whole-brain anterograde tracing parsed dorsal striatum into domains and traced their multisynaptic outputs through GPe, SNr, thalamic nuclei back to cortex; six closed parallel subnetworks emerged in mouse, with thalamic domains relaying back to the originating corticostriatal neurons.",
  "effect_size": "6 subnetworks; 14 SNr domains; 36 GPe domains; 29 striatal domains",
  "text_access": "fulltext",
  "study_system": "mouse cortico-basal ganglia-thalamic mesoscale tracing",
  "source_cluster_id": "cluster_06",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Subsequently, we identify six parallel cortico–basal ganglia–thalamic subnetworks that sequentially transduce specific subsets of cortical information through every elemental node of the cortico–basal ganglia–thalamic loop.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Accordingly, we identify 14 SNr and 36 GPe domains and a direct cortico-SNr projection."
}

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Whole-brain anterograde tracing parsed dorsal striatum into domains and traced their multisynaptic outputs through GPe, SNr, thalamic nuclei back to cortex; six closed parallel subnetworks emerged in mouse, with thalamic domains relaying back to the originating corticostriatal neurons.