Details

scope
rat
section_id
section_06
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json
effect_size
1
review_repo
ComputationalReviewVIP
section_ref
wiki_page:computationalreviewvip-06-synaptic-properties
source_kind
review_finding
source_path
evidence/section_06_evidence_package.json
source_span
The lithium-pilocarpine rat model of status epilepticus (SE) is a well-established paradigm for studying epileptogenesis.
study_system
rat
section_title
Synaptic Properties and Connectivity
evidence_summary
Reported in Biomolecules (2025); from Body of abstract.
review_bundle_ref
analysis_bundle:ab-2ce40c33e827
replication_status
replication_unknown
review_package_ref
analysis_bundle:ab-2ce40c33e827
source_artifact_ref
wiki_page:computationalreviewvip-06-synaptic-properties
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json
commit_sha
95e761177f7d2ec565983d3307c14ec238f9677c
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
claim_text
Inhibition of Astrocyte Reactivity by Mdivi-1 After Status Epilepticus in Rats Exacerbates Microglia-Mediated Neuroinflammation and Impairs Limbic-Cortical Glucose Metabolism — The lithium-pilocarpine rat model of status epilepticus (SE) is a well-established paradigm for studying epileptogenesis
raw_fields
{
  "n": 0,
  "doi": "10.3390/biom15091242",
  "claim": "Inhibition of Astrocyte Reactivity by Mdivi-1 After Status Epilepticus in Rats Exacerbates Microglia-Mediated Neuroinflammation and Impairs Limbic-Cortical Glucose Metabolism — The lithium-pilocarpine rat model of status epilepticus (SE) is a well-established paradigm for studying epileptogenesis",
  "title": null,
  "cite_key": "Gomezoliver2025",
  "evidence": "Reported in Biomolecules (2025); from Body of abstract.",
  "effect_size": "1",
  "text_access": "abstract_only",
  "study_system": "rat",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 396,
  "claim_source_sentence": "The lithium-pilocarpine rat model of status epilepticus (SE) is a well-established paradigm for studying epileptogenesis.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Herein, we evaluated the effects of Mdivi-1, a pharmacological inhibitor of mitochondrial fission protein Drp1, for its ability to modulate astrocytic mitochondrial dynamics and for its reported preventive neuroprotective properties."
}
source_refs
[
  "paper:paper-0f65cd37e259"
]
evidence_refs
[
  {
    "ref": "paper:paper-0f65cd37e259"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

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