Version history

{
  "scope": "rat",
  "claim_text": "Inhibition of Astrocyte Reactivity by Mdivi-1 After Status Epilepticus in Rats Exacerbates Microglia-Mediated Neuroinflammation and Impairs Limbic-Cortical Glucose Metabolism — The lithium-pilocarpine rat model of status epilepticus (SE) is a well-established paradigm for studying epileptogenesis",
  "raw_fields": {
    "n": 0,
    "doi": "10.3390/biom15091242",
    "claim": "Inhibition of Astrocyte Reactivity by Mdivi-1 After Status Epilepticus in Rats Exacerbates Microglia-Mediated Neuroinflammation and Impairs Limbic-Cortical Glucose Metabolism — The lithium-pilocarpine rat model of status epilepticus (SE) is a well-established paradigm for studying epileptogenesis",
    "title": null,
    "cite_key": "Gomezoliver2025",
    "evidence": "Reported in Biomolecules (2025); from Body of abstract.",
    "effect_size": "1",
    "text_access": "abstract_only",
    "study_system": "rat",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 396,
    "claim_source_sentence": "The lithium-pilocarpine rat model of status epilepticus (SE) is a well-established paradigm for studying epileptogenesis.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Herein, we evaluated the effects of Mdivi-1, a pharmacological inhibitor of mitochondrial fission protein Drp1, for its ability to modulate astrocytic mitochondrial dynamics and for its reported preventive neuroprotective properties."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "1",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-0f65cd37e259"
  ],
  "source_span": "The lithium-pilocarpine rat model of status epilepticus (SE) is a well-established paradigm for studying epileptogenesis.",
  "study_system": "rat",
  "evidence_refs": [
    {
      "ref": "paper:paper-0f65cd37e259"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Reported in Biomolecules (2025); from Body of abstract.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}