Details
- scope
- mouse motor cortex IT neurons, Tlx3-Cre line, chemogenetics, open field
- section_id
- section_01
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_01_evidence_package.json
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-01-introduction
- source_kind
- review_finding
- source_path
- evidence/section_01_evidence_package.json
- source_span
- Bilateral chemogenetic activation of intratelencephalic Tlx3neurons in the mouse motor cortex reduced spontaneous locomotor activity in the open field, increasing states of freezing and immobility.
- study_system
- mouse motor cortex IT neurons, Tlx3-Cre line, chemogenetics, open field
- section_title
- 1. Introduction — what "excitatory recurrence" means operationally in mouse cortex, and why isolating it from inhibition and from clinical framings is a defensible analytic move for basic-research synthesis
- evidence_summary
- Cre-dependent DREADD activation of Tlx3-Cre+ IT neurons in mouse motor cortex with open-field assessment using CNO and deschloroclozapine.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-01-introduction
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_01_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
- claim_text
Bilateral chemogenetic activation of Tlx3-Cre intratelencephalic neurons in mouse motor cortex reduces spontaneous open-field locomotion and increases freezing/immobility, establishing a causal link between IT-class activity and motor output.
- raw_fields
{ "n": null, "doi": "10.1016/j.nbd.2024.106755", "claim": "Bilateral chemogenetic activation of Tlx3-Cre intratelencephalic neurons in mouse motor cortex reduces spontaneous open-field locomotion and increases freezing/immobility, establishing a causal link between IT-class activity and motor output.", "cite_key": "Atudorei2025", "evidence": "Cre-dependent DREADD activation of Tlx3-Cre+ IT neurons in mouse motor cortex with open-field assessment using CNO and deschloroclozapine.", "effect_size": null, "text_access": "abstract_only", "study_system": "mouse motor cortex IT neurons, Tlx3-Cre line, chemogenetics, open field", "argument_role": "supporting", "replication_status": "replication_unknown", "claim_source_sentence": "Bilateral chemogenetic activation of intratelencephalic Tlx3neurons in the mouse motor cortex reduced spontaneous locomotor activity in the open field, increasing states of freezing and immobility.", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-c4e7f2a4e77a" ]
- evidence_refs
[ { "ref": "paper:paper-c4e7f2a4e77a" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }