- raw_fields
{
"n": 0,
"doi": "10.1016/j.tins.2011.10.004",
"claim": "Cortical gamma oscillations require strong inhibitory inputs to pyramidal neurons from PV basket cells, and schizophrenia is associated with multiple pre- and post-synaptic abnormalities in PVBCs that weaken their inhibitory control",
"evidence": "Review of prefrontal cortex gamma oscillation deficits and PV basket cell abnormalities in schizophrenia",
"effect_size": "PVBC inhibition decreased to compensate for upstream deficit in pyramidal cell excitation",
"text_access": "fulltext",
"study_system": "review of human prefrontal cortex in schizophrenia",
"replication_status": "independently replicated",
"claim_source_sentence": "Cortical gamma oscillations require strong inhibitory inputs to pyramidal neurons from the parvalbumin basket cell (PVBC) class of GABAergic neurons. Recent findings indicate that schizophrenia is associated with multiple pre- and post-synaptic abnormalities in PVBCs, each of which weakens their inhibitory control of pyramidal cells.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "This compensation is thought to re-balance cortical excitation and inhibition, but at a level insufficient to generate the gamma oscillation power required for high levels of cognitive control."
}- source_refs
[
"paper:paper-6d36973b50ab"
]
- source_span
Cortical gamma oscillations require strong inhibitory inputs to pyramidal neurons from the parvalbumin basket cell (PVBC) class of GABAergic neurons. Recent findings indicate that schizophrenia is associated with multiple pre- and post-synaptic abnormalities in PVBCs, each of which weakens their inhibitory control of pyramidal cells.
- evidence_refs
[
{
"ref": "paper:paper-6d36973b50ab"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}