Version history

{
  "scope": "review of human prefrontal cortex in schizophrenia",
  "claim_text": "Cortical gamma oscillations require strong inhibitory inputs to pyramidal neurons from PV basket cells, and schizophrenia is associated with multiple pre- and post-synaptic abnormalities in PVBCs that weaken their inhibitory control",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.tins.2011.10.004",
    "claim": "Cortical gamma oscillations require strong inhibitory inputs to pyramidal neurons from PV basket cells, and schizophrenia is associated with multiple pre- and post-synaptic abnormalities in PVBCs that weaken their inhibitory control",
    "evidence": "Review of prefrontal cortex gamma oscillation deficits and PV basket cell abnormalities in schizophrenia",
    "effect_size": "PVBC inhibition decreased to compensate for upstream deficit in pyramidal cell excitation",
    "text_access": "fulltext",
    "study_system": "review of human prefrontal cortex in schizophrenia",
    "replication_status": "independently replicated",
    "claim_source_sentence": "Cortical gamma oscillations require strong inhibitory inputs to pyramidal neurons from the parvalbumin basket cell (PVBC) class of GABAergic neurons. Recent findings indicate that schizophrenia is associated with multiple pre- and post-synaptic abnormalities in PVBCs, each of which weakens their inhibitory control of pyramidal cells.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "This compensation is thought to re-balance cortical excitation and inhibition, but at a level insufficient to generate the gamma oscillation power required for high levels of cognitive control."
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "effect_size": "PVBC inhibition decreased to compensate for upstream deficit in pyramidal cell excitation",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-6d36973b50ab"
  ],
  "source_span": "Cortical gamma oscillations require strong inhibitory inputs to pyramidal neurons from the parvalbumin basket cell (PVBC) class of GABAergic neurons. Recent findings indicate that schizophrenia is associated with multiple pre- and post-synaptic abnormalities in PVBCs, each of which weakens their inhibitory control of pyramidal cells.",
  "study_system": "review of human prefrontal cortex in schizophrenia",
  "evidence_refs": [
    {
      "ref": "paper:paper-6d36973b50ab"
    }
  ],
  "section_title": "Local Circuit Motifs: Perisomatic Inhibition, Feedback, and Feedforward",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Review of prefrontal cortex gamma oscillation deficits and PV basket cell abnormalities in schizophrenia",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}