Version history

{
  "scope": "review of mouse cortex VIP intrinsic-physiology literature",
  "claim_text": "The most salient intrinsic-electrophysiology feature of cortical Vip interneurons is their relatively *high input resistance*, higher than most cortical neurons; this property makes them especially sensitive to weak excitatory inputs (e.g., thalamic input to L4/deep-L3 Vip cells produces weak EPSCs but substantial depolarization due to high R_in), and likely underpins their characteristic irregular-spiking firing because subthreshold noise, oscillations, or small synaptic events can reach spike threshold.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2016.06.033",
    "claim": "The most salient intrinsic-electrophysiology feature of cortical Vip interneurons is their relatively *high input resistance*, higher than most cortical neurons; this property makes them especially sensitive to weak excitatory inputs (e.g., thalamic input to L4/deep-L3 Vip cells produces weak EPSCs but substantial depolarization due to high R_in), and likely underpins their characteristic irregular-spiking firing because subthreshold noise, oscillations, or small synaptic events can reach spike threshold.",
    "title": null,
    "cite_key": "Tremblay2016",
    "evidence": "Tremblay 2016 review (consolidating Cauli, Lee, Porter, Pronneke)",
    "effect_size": "qualitative — Vip R_in highest of cortical INs; correlates with irregular spiking",
    "text_access": "fulltext",
    "study_system": "review of mouse cortex VIP intrinsic-physiology literature",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 88,
    "claim_source_sentence": "Perhaps, the most salient intrinsic electrophysiological feature of Vip INs is their relatively high input resistance, higher than most cortical neurons.",
    "replication_evidence_dois": [
      "10.1093/cercor/bhp310",
      "10.1093/cercor/bhv202",
      "10.1016/j.cell.2020.09.057"
    ],
    "effect_size_source_sentence": "Irregular spiking might be seen often in Vip cells as a result of their high input resistance, which increases the possibility that noise, an intrinsic subthreshold oscillation, or a small synaptic input will produce sufficient depolarization to reach spike threshold."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "qualitative — Vip R_in highest of cortical INs; correlates with irregular spiking",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-53c8505de50f"
  ],
  "source_span": "Perhaps, the most salient intrinsic electrophysiological feature of Vip INs is their relatively high input resistance, higher than most cortical neurons.",
  "study_system": "review of mouse cortex VIP intrinsic-physiology literature",
  "evidence_refs": [
    {
      "ref": "paper:paper-53c8505de50f"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Tremblay 2016 review (consolidating Cauli, Lee, Porter, Pronneke)",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}