The most salient intrinsic-electrophysiology feature of cortical Vip interneuro…

The most salient intrinsic-electrophysiology feature of cortical Vip interneurons is their relatively *high input resistance*, higher than most cortical neurons; this property makes them especially sensitive to weak excitatory inputs (e.g., thalamic input to L4/deep-L3 Vip cells produces weak EPSCs but substantial depolarization due to high R_in), and likely underpins their characteristic irregular-spiking firing because subthreshold noise, oscillations, or small synaptic events can reach spike threshold.

{
  "n": null,
  "doi": "10.1016/j.neuron.2016.06.033",
  "claim": "The most salient intrinsic-electrophysiology feature of cortical Vip interneurons is their relatively *high input resistance*, higher than most cortical neurons; this property makes them especially sensitive to weak excitatory inputs (e.g., thalamic input to L4/deep-L3 Vip cells produces weak EPSCs but substantial depolarization due to high R_in), and likely underpins their characteristic irregular-spiking firing because subthreshold noise, oscillations, or small synaptic events can reach spike threshold.",
  "title": null,
  "cite_key": "Tremblay2016",
  "evidence": "Tremblay 2016 review (consolidating Cauli, Lee, Porter, Pronneke)",
  "effect_size": "qualitative — Vip R_in highest of cortical INs; correlates with irregular spiking",
  "text_access": "fulltext",
  "study_system": "review of mouse cortex VIP intrinsic-physiology literature",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 88,
  "claim_source_sentence": "Perhaps, the most salient intrinsic electrophysiological feature of Vip INs is their relatively high input resistance, higher than most cortical neurons.",
  "replication_evidence_dois": [
    "10.1093/cercor/bhp310",
    "10.1093/cercor/bhv202",
    "10.1016/j.cell.2020.09.057"
  ],
  "effect_size_source_sentence": "Irregular spiking might be seen often in Vip cells as a result of their high input resistance, which increases the possibility that noise, an intrinsic subthreshold oscillation, or a small synaptic input will produce sufficient depolarization to reach spike threshold."
}

[
  "paper:paper-53c8505de50f"
]

[
  {
    "ref": "paper:paper-53c8505de50f"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}