Version history

{
  "scope": "human, diffusion MRI tractography",
  "claim_text": "In 100 healthy human subjects, frontostriatal wiring deviates from strict topographic organization due to regionally specific convergence from ventrolateral, dorsolateral, and orbitofrontal PFC subregions onto the caudate.",
  "raw_fields": {
    "n": 100,
    "doi": "10.1093/cercor/bhab159",
    "claim": "In 100 healthy human subjects, frontostriatal wiring deviates from strict topographic organization due to regionally specific convergence from ventrolateral, dorsolateral, and orbitofrontal PFC subregions onto the caudate.",
    "cite_key": "Levitt2021",
    "evidence": "Diffusion MRI tractography in N=100 healthy adults identified 17 frontal-caudate fiber clusters per hemisphere; quantitative cluster convergence revealed deviations from a strict topographic Alexander schema.",
    "effect_size": "N=100; 17 clusters per hemisphere",
    "text_access": "abstract_only",
    "study_system": "human, diffusion MRI tractography",
    "source_cluster_id": "cluster_06",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "We show first, the overall frontal cortex wiring pattern of the caudate deviates from a strictly topographic organization due to significantly greater convergence in regionally specific clusters; second, these significantly convergent clusters originate in subregions of ventrolateral, dorsolateral, and orbitofrontal prefrontal cortex (PFC); and, third, a similar organization in both hemispheres.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "To assess normal organization of frontostriatal brain wiring, we analyzed diffusion magnetic resonance imaging (dMRI) scans in 100 young adult healthy subjects (HSs)."
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_07_evidence_package.json",
  "effect_size": "N=100; 17 clusters per hemisphere",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-8dce83b8881b"
  ],
  "source_span": "We show first, the overall frontal cortex wiring pattern of the caudate deviates from a strictly topographic organization due to significantly greater convergence in regionally specific clusters; second, these significantly convergent clusters originate in subregions of ventrolateral, dorsolateral, and orbitofrontal prefrontal cortex (PFC); and, third, a similar organization in both hemispheres.",
  "study_system": "human, diffusion MRI tractography",
  "evidence_refs": [
    {
      "ref": "paper:paper-8dce83b8881b"
    }
  ],
  "section_title": "Parallel Loop Channels: Motor, Limbic, Associative, and Beyond the Classic Three",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Diffusion MRI tractography in N=100 healthy adults identified 17 frontal-caudate fiber clusters per hemisphere; quantitative cluster convergence revealed deviations from a strict topographic Alexander schema.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_07_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}