Version history

{
  "scope": "mouse, Lhx6 loxP/loxP with adult Cre expression (>8 weeks)",
  "claim_text": "Postnatal removal of Lhx6 does not affect PV interneuron number, morphology, or physiological properties, suggesting Lhx6 becomes uncoupled from downstream effectors in adulthood",
  "raw_fields": {
    "n": 8,
    "doi": "10.1038/s41598-022-09003-4",
    "claim": "Postnatal removal of Lhx6 does not affect PV interneuron number, morphology, or physiological properties, suggesting Lhx6 becomes uncoupled from downstream effectors in adulthood",
    "evidence": "While Lhx6 is essential embryonically, adult-expressed Lhx6 is dispensable; only partially reduces Sox6 and Arx expression postnatally",
    "effect_size": "no change in PV interneuron number or properties after adult Lhx6 removal",
    "text_access": "fulltext",
    "study_system": "mouse, Lhx6 loxP/loxP with adult Cre expression (>8 weeks)",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Late removal of Lhx6 did not affect the number of PVIs and had no impact on the morphological and physiological properties of PVIs.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Late removal of Lhx6 did not affect the number of PVIs and had no impact on the morphological and physiological properties of PVIs."
  },
  "section_id": "section_03_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json",
  "effect_size": "no change in PV interneuron number or properties after adult Lhx6 removal",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-03",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-c3822417e928"
  ],
  "source_span": "Late removal of Lhx6 did not affect the number of PVIs and had no impact on the morphological and physiological properties of PVIs.",
  "study_system": "mouse, Lhx6 loxP/loxP with adult Cre expression (>8 weeks)",
  "evidence_refs": [
    {
      "ref": "paper:paper-c3822417e928"
    }
  ],
  "section_title": "Developmental Origins: MGE Lineage, Specification, and Migration",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "While Lhx6 is essential embryonically, adult-expressed Lhx6 is dispensable; only partially reduces Sox6 and Arx expression postnatally",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-03",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}