Postnatal removal of Lhx6 does not affect PV interneuron number, morphology, or…

Details

scope: mouse, Lhx6 loxP/loxP with adult Cre expression (>8 weeks)
claim_text: Postnatal removal of Lhx6 does not affect PV interneuron number, morphology, or physiological properties, suggesting Lhx6 becomes uncoupled from downstream effectors in adulthood
section_id: section_03_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
effect_size: no change in PV interneuron number or properties after adult Lhx6 removal
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-03
source_kind: review_finding
source_path: evidence/section_03_evidence_package.json
source_span: Late removal of Lhx6 did not affect the number of PVIs and had no impact on the morphological and physiological properties of PVIs.
study_system: mouse, Lhx6 loxP/loxP with adult Cre expression (>8 weeks)
section_title: Developmental Origins: MGE Lineage, Specification, and Migration
evidence_summary: While Lhx6 is essential embryonically, adult-expressed Lhx6 is dispensable; only partially reduces Sox6 and Arx expression postnatally
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-03
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 8,
  "doi": "10.1038/s41598-022-09003-4",
  "claim": "Postnatal removal of Lhx6 does not affect PV interneuron number, morphology, or physiological properties, suggesting Lhx6 becomes uncoupled from downstream effectors in adulthood",
  "evidence": "While Lhx6 is essential embryonically, adult-expressed Lhx6 is dispensable; only partially reduces Sox6 and Arx expression postnatally",
  "effect_size": "no change in PV interneuron number or properties after adult Lhx6 removal",
  "text_access": "fulltext",
  "study_system": "mouse, Lhx6 loxP/loxP with adult Cre expression (>8 weeks)",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Late removal of Lhx6 did not affect the number of PVIs and had no impact on the morphological and physiological properties of PVIs.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Late removal of Lhx6 did not affect the number of PVIs and had no impact on the morphological and physiological properties of PVIs."
}

source_refs

[
  "paper:paper-c3822417e928"
]

evidence_refs

[
  {
    "ref": "paper:paper-c3822417e928"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

Postnatal removal of Lhx6 does not affect PV interneuron number, morphology, or…

Details

Replication

Discussion