Version history

{
  "scope": "rodent mPFC; in vitro slice + behavior",
  "claim_text": "ChAT-expressing VIP interneurons in rodent mPFC are a local cortical source of acetylcholine that directly excites both interneurons in L1–3 and pyramidal neurons in L2/3 and L6 via fast cholinergic synaptic transmission; ~10–20% of postsynaptic targets also receive GABAergic input from the same ChAT-VIP cell, and unlike regular VIP cells, ChAT-VIP cells do not disinhibit pyramidal neurons.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41467-019-13244-9",
    "claim": "ChAT-expressing VIP interneurons in rodent mPFC are a local cortical source of acetylcholine that directly excites both interneurons in L1–3 and pyramidal neurons in L2/3 and L6 via fast cholinergic synaptic transmission; ~10–20% of postsynaptic targets also receive GABAergic input from the same ChAT-VIP cell, and unlike regular VIP cells, ChAT-VIP cells do not disinhibit pyramidal neurons.",
    "title": null,
    "cite_key": "Obermayer2019",
    "evidence": "Channelrhodopsin photo-activation of ChAT-Cre x VIP neurons + paired whole-cell recordings in mPFC slices; behavioral attention testing.",
    "effect_size": "10–20% of cells receive both ACh and GABA from same ChAT-VIP neuron",
    "text_access": "abstract_only",
    "study_system": "rodent mPFC; in vitro slice + behavior",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "single-study",
    "_source_cluster_index": 26,
    "claim_source_sentence": "Both interneurons in layers (L)1-3 as well as pyramidal neurons in L2/3 and L6 receive direct inputs from ChAT-VIP neurons mediated by fast cholinergic transmission. A fraction (10-20%) of postsynaptic neurons that received cholinergic input from ChAT-VIP interneurons also received GABAergic input from these neurons.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "A fraction (10-20%) of postsynaptic neurons that received cholinergic input from ChAT-VIP interneurons also received GABAergic input from these neurons."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "10–20% of cells receive both ACh and GABA from same ChAT-VIP neuron",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-d66bdd18df1c"
  ],
  "source_span": "Both interneurons in layers (L)1-3 as well as pyramidal neurons in L2/3 and L6 receive direct inputs from ChAT-VIP neurons mediated by fast cholinergic transmission. A fraction (10-20%) of postsynaptic neurons that received cholinergic input from ChAT-VIP interneurons also received GABAergic input from these neurons.",
  "study_system": "rodent mPFC; in vitro slice + behavior",
  "evidence_refs": [
    {
      "ref": "paper:paper-d66bdd18df1c"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Channelrhodopsin photo-activation of ChAT-Cre x VIP neurons + paired whole-cell recordings in mPFC slices; behavioral attention testing.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}