ChAT-expressing VIP interneurons in rodent mPFC are a local cortical source of…

ChAT-expressing VIP interneurons in rodent mPFC are a local cortical source of acetylcholine that directly excites both interneurons in L1–3 and pyramidal neurons in L2/3 and L6 via fast cholinergic synaptic transmission; ~10–20% of postsynaptic targets also receive GABAergic input from the same ChAT-VIP cell, and unlike regular VIP cells, ChAT-VIP cells do not disinhibit pyramidal neurons.

{
  "n": null,
  "doi": "10.1038/s41467-019-13244-9",
  "claim": "ChAT-expressing VIP interneurons in rodent mPFC are a local cortical source of acetylcholine that directly excites both interneurons in L1–3 and pyramidal neurons in L2/3 and L6 via fast cholinergic synaptic transmission; ~10–20% of postsynaptic targets also receive GABAergic input from the same ChAT-VIP cell, and unlike regular VIP cells, ChAT-VIP cells do not disinhibit pyramidal neurons.",
  "title": null,
  "cite_key": "Obermayer2019",
  "evidence": "Channelrhodopsin photo-activation of ChAT-Cre x VIP neurons + paired whole-cell recordings in mPFC slices; behavioral attention testing.",
  "effect_size": "10–20% of cells receive both ACh and GABA from same ChAT-VIP neuron",
  "text_access": "abstract_only",
  "study_system": "rodent mPFC; in vitro slice + behavior",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "single-study",
  "_source_cluster_index": 26,
  "claim_source_sentence": "Both interneurons in layers (L)1-3 as well as pyramidal neurons in L2/3 and L6 receive direct inputs from ChAT-VIP neurons mediated by fast cholinergic transmission. A fraction (10-20%) of postsynaptic neurons that received cholinergic input from ChAT-VIP interneurons also received GABAergic input from these neurons.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "A fraction (10-20%) of postsynaptic neurons that received cholinergic input from ChAT-VIP interneurons also received GABAergic input from these neurons."
}

[
  "paper:paper-d66bdd18df1c"
]

Both interneurons in layers (L)1-3 as well as pyramidal neurons in L2/3 and L6 receive direct inputs from ChAT-VIP neurons mediated by fast cholinergic transmission. A fraction (10-20%) of postsynaptic neurons that received cholinergic input from ChAT-VIP interneurons also received GABAergic input from these neurons.

[
  {
    "ref": "paper:paper-d66bdd18df1c"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}