Details

scope
mouse primary visual cortex (V1), layer 2/3 pyramidal neurons; in vivo two-photon Ca imaging followed by in vitro paired patch recordings
claim_text
In mouse V1 L2/3 pyramidal neurons, connection probability depends on functional similarity: neurons sharing orientation preference connect at roughly twice the rate of neurons with orthogonal preferences.
section_id
section_05
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json
effect_size
~2× connection probability for same-orientation vs orthogonal pairs
review_repo
ComputationalReviewRecurrence
section_ref
wiki_page:computationalreviewrecurrence-05-horizontal
source_kind
review_finding
source_path
evidence/section_05_evidence_package.json
source_span
Neurons with the same preference for oriented stimuli connected at twice the rate of neurons with orthogonal orientation preferences.
study_system
mouse primary visual cortex (V1), layer 2/3 pyramidal neurons; in vivo two-photon Ca imaging followed by in vitro paired patch recordings
section_title
5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay
evidence_summary
Multipatch whole-cell recordings in V1 L2/3 slices from animals first imaged in vivo with two-photon calcium imaging. Connection probability scored against tuning similarity.
review_bundle_ref
analysis_bundle:ab-d9c479db9be9
replication_status
independently_replicated
review_package_ref
analysis_bundle:ab-d9c479db9be9
source_artifact_ref
wiki_page:computationalreviewrecurrence-05-horizontal
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json
commit_sha
79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (4)
raw_fields
{
  "n": 0,
  "doi": "10.1038/nature09880",
  "claim": "In mouse V1 L2/3 pyramidal neurons, connection probability depends on functional similarity: neurons sharing orientation preference connect at roughly twice the rate of neurons with orthogonal preferences.",
  "cite_key": "Ko2011",
  "evidence": "Multipatch whole-cell recordings in V1 L2/3 slices from animals first imaged in vivo with two-photon calcium imaging. Connection probability scored against tuning similarity.",
  "effect_size": "~2× connection probability for same-orientation vs orthogonal pairs",
  "text_access": "abstract_only",
  "study_system": "mouse primary visual cortex (V1), layer 2/3 pyramidal neurons; in vivo two-photon Ca imaging followed by in vitro paired patch recordings",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Neurons with the same preference for oriented stimuli connected at twice the rate of neurons with orthogonal orientation preferences.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nature14182",
    "10.1038/nature17192",
    "10.1038/s41586-025-08840-3"
  ],
  "effect_size_source_sentence": "Neurons with the same preference for oriented stimuli connected at twice the rate of neurons with orthogonal orientation preferences."
}
source_refs
[
  "paper:paper-31c9e0b4d258"
]
evidence_refs
[
  {
    "ref": "paper:paper-31c9e0b4d258"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

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