Version history

{
  "scope": "Mouse V1 L4, awake; in vivo whole-cell + optogenetic cortical silencing",
  "claim_text": "In mouse V1 L4, thalamic excitation supplies only ~1/3 of total excitation onto neurons; recurrent cortical circuits amplify this tuned thalamic input, providing a direct quantitative measurement of cortical E→E recurrent gain on the feedforward signal.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nn.3488",
    "claim": "In mouse V1 L4, thalamic excitation supplies only ~1/3 of total excitation onto neurons; recurrent cortical circuits amplify this tuned thalamic input, providing a direct quantitative measurement of cortical E→E recurrent gain on the feedforward signal.",
    "cite_key": "Lien2013",
    "evidence": "In vivo whole-cell recording in mouse V1 L4 with optogenetic silencing of cortex (LP/Arch) to isolate thalamic excitatory input during visual stimulation; comparison to total excitation.",
    "effect_size": "thalamic excitation = ~1/3 of total excitation onto L4 neurons; both thalamic and total excitation similarly orientation-tuned (cortex amplifies, not creates, tuning)",
    "text_access": "abstract_only",
    "study_system": "Mouse V1 L4, awake; in vivo whole-cell + optogenetic cortical silencing",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Thalamic excitation contributed to a third of the total excitation and was organized in spatially offset, yet overlapping, ON and OFF receptive fields.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1371/journal.pcbi.1005576",
      "10.1038/nn.4196"
    ],
    "effect_size_source_sentence": "Thalamic excitation contributed to a third of the total excitation and was organized in spatially offset, yet overlapping, ON and OFF receptive fields."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "thalamic excitation = ~1/3 of total excitation onto L4 neurons; both thalamic and total excitation similarly orientation-tuned (cortex amplifies, not creates, tuning)",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-db387d9e0e61"
  ],
  "source_span": "Thalamic excitation contributed to a third of the total excitation and was organized in spatially offset, yet overlapping, ON and OFF receptive fields.",
  "study_system": "Mouse V1 L4, awake; in vivo whole-cell + optogenetic cortical silencing",
  "evidence_refs": [
    {
      "ref": "paper:paper-db387d9e0e61"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "In vivo whole-cell recording in mouse V1 L4 with optogenetic silencing of cortex (LP/Arch) to isolate thalamic excitatory input during visual stimulation; comparison to total excitation.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}