In mouse V1 L4, thalamic excitation supplies only ~1/3 of total excitation onto…

In mouse V1 L4, thalamic excitation supplies only ~1/3 of total excitation onto neurons; recurrent cortical circuits amplify this tuned thalamic input, providing a direct quantitative measurement of cortical E→E recurrent gain on the feedforward signal.

{
  "n": 0,
  "doi": "10.1038/nn.3488",
  "claim": "In mouse V1 L4, thalamic excitation supplies only ~1/3 of total excitation onto neurons; recurrent cortical circuits amplify this tuned thalamic input, providing a direct quantitative measurement of cortical E→E recurrent gain on the feedforward signal.",
  "cite_key": "Lien2013",
  "evidence": "In vivo whole-cell recording in mouse V1 L4 with optogenetic silencing of cortex (LP/Arch) to isolate thalamic excitatory input during visual stimulation; comparison to total excitation.",
  "effect_size": "thalamic excitation = ~1/3 of total excitation onto L4 neurons; both thalamic and total excitation similarly orientation-tuned (cortex amplifies, not creates, tuning)",
  "text_access": "abstract_only",
  "study_system": "Mouse V1 L4, awake; in vivo whole-cell + optogenetic cortical silencing",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Thalamic excitation contributed to a third of the total excitation and was organized in spatially offset, yet overlapping, ON and OFF receptive fields.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1371/journal.pcbi.1005576",
    "10.1038/nn.4196"
  ],
  "effect_size_source_sentence": "Thalamic excitation contributed to a third of the total excitation and was organized in spatially offset, yet overlapping, ON and OFF receptive fields."
}

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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