Version history

{
  "scope": "mouse hand/forelimb sensorimotor circuit (cuneate → VPL → S1 → M1)",
  "claim_text": "The mouse hand/forelimb transcortical sensorimotor circuit is structurally asymmetric: the lemnisco-cortical leg traverses ~1 cm via a single excitatory thalamic synapse, while the corticocortical S1→M1 leg spans only ~1 mm but is densely polysynaptic, engaging multiple intratelencephalic (IT) subtypes in S1 L2-L5A and in M1 L2/3 before reaching M1 corticospinal neurons.",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.66836",
    "claim": "The mouse hand/forelimb transcortical sensorimotor circuit is structurally asymmetric: the lemnisco-cortical leg traverses ~1 cm via a single excitatory thalamic synapse, while the corticocortical S1→M1 leg spans only ~1 mm but is densely polysynaptic, engaging multiple intratelencephalic (IT) subtypes in S1 L2-L5A and in M1 L2/3 before reaching M1 corticospinal neurons.",
    "cite_key": "Yamawaki2021",
    "evidence": "Cre-dependent PRV-Introvert polysynaptic tracing, ChR2-assisted circuit mapping and paired patch-clamp electrophysiology along the cuneate→VPL→S1→M1→corticospinal axis in mouse.",
    "effect_size": "qualitative — strong asymmetry in synapse count between lemnisco-cortical and corticocortical legs",
    "text_access": "fulltext",
    "study_system": "mouse hand/forelimb sensorimotor circuit (cuneate → VPL → S1 → M1)",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "the sharp contrast between the 'streamlined' organization of the lemnisco-cortical leg of the circuit, spanning the relatively large ~1 cm distance from cuneate to cortex via a single excitatory synapse in thalamus, and the densely polysynaptic organization of the corticocortical leg of the circuit, linking S1 to M1 across a mere ~1 mm distance but through complex circuits that engage multiple subtypes of intratelencephalic (IT) neurons",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "spanning the relatively large ~1 cm distance from cuneate to cortex via a single excitatory synapse in thalamus, and the densely polysynaptic organization of the corticocortical leg"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — strong asymmetry in synapse count between lemnisco-cortical and corticocortical legs",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-15b98c6c015d"
  ],
  "source_span": "the sharp contrast between the 'streamlined' organization of the lemnisco-cortical leg of the circuit, spanning the relatively large ~1 cm distance from cuneate to cortex via a single excitatory synapse in thalamus, and the densely polysynaptic organization of the corticocortical leg of the circuit, linking S1 to M1 across a mere ~1 mm distance but through complex circuits that engage multiple subtypes of intratelen...",
  "study_system": "mouse hand/forelimb sensorimotor circuit (cuneate → VPL → S1 → M1)",
  "evidence_refs": [
    {
      "ref": "paper:paper-15b98c6c015d"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Cre-dependent PRV-Introvert polysynaptic tracing, ChR2-assisted circuit mapping and paired patch-clamp electrophysiology along the cuneate→VPL→S1→M1→corticospinal axis in mouse.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}