The mouse hand/forelimb transcortical sensorimotor circuit is structurally asym…

The mouse hand/forelimb transcortical sensorimotor circuit is structurally asymmetric: the lemnisco-cortical leg traverses ~1 cm via a single excitatory thalamic synapse, while the corticocortical S1→M1 leg spans only ~1 mm but is densely polysynaptic, engaging multiple intratelencephalic (IT) subtypes in S1 L2-L5A and in M1 L2/3 before reaching M1 corticospinal neurons.

{
  "n": 0,
  "doi": "10.7554/elife.66836",
  "claim": "The mouse hand/forelimb transcortical sensorimotor circuit is structurally asymmetric: the lemnisco-cortical leg traverses ~1 cm via a single excitatory thalamic synapse, while the corticocortical S1→M1 leg spans only ~1 mm but is densely polysynaptic, engaging multiple intratelencephalic (IT) subtypes in S1 L2-L5A and in M1 L2/3 before reaching M1 corticospinal neurons.",
  "cite_key": "Yamawaki2021",
  "evidence": "Cre-dependent PRV-Introvert polysynaptic tracing, ChR2-assisted circuit mapping and paired patch-clamp electrophysiology along the cuneate→VPL→S1→M1→corticospinal axis in mouse.",
  "effect_size": "qualitative — strong asymmetry in synapse count between lemnisco-cortical and corticocortical legs",
  "text_access": "fulltext",
  "study_system": "mouse hand/forelimb sensorimotor circuit (cuneate → VPL → S1 → M1)",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "the sharp contrast between the 'streamlined' organization of the lemnisco-cortical leg of the circuit, spanning the relatively large ~1 cm distance from cuneate to cortex via a single excitatory synapse in thalamus, and the densely polysynaptic organization of the corticocortical leg of the circuit, linking S1 to M1 across a mere ~1 mm distance but through complex circuits that engage multiple subtypes of intratelencephalic (IT) neurons",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "spanning the relatively large ~1 cm distance from cuneate to cortex via a single excitatory synapse in thalamus, and the densely polysynaptic organization of the corticocortical leg"
}

[
  "paper:paper-15b98c6c015d"
]

the sharp contrast between the 'streamlined' organization of the lemnisco-cortical leg of the circuit, spanning the relatively large ~1 cm distance from cuneate to cortex via a single excitatory synapse in thalamus, and the densely polysynaptic organization of the corticocortical leg of the circuit, linking S1 to M1 across a mere ~1 mm distance but through complex circuits that engage multiple subtypes of intratelen...

[
  {
    "ref": "paper:paper-15b98c6c015d"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}