GZMK+ CD8+ T cells expand with age and are detectable across multiple non-lymphoid tissues in older adults, consistent with a systemic inflammaging signature rather than a tissue-resident phenomenon. Mogilenko et al. (2021, Immunity) reported clonal GZMK+ CD8+ T cell expansion as a conserved hallmark across donors, with 588 citations confirming canonical status.
Details
- local_id
- claim-t184-01
- confidence
- high
- created_by
- persona-claire-gustavson
Raw fields (2)
- tags
[ "GZMK", "CD8", "inflammaging", "aging-cohort", "tissue-distribution" ]
- links
{ "source_papers": [ "doi:10.1016/j.immuni.2020.11.005" ], "source_datasets": [], "supporting_figures": [] }