Version history

1 version on record. Newest first; the live version sits at the top with a live indicator.

  1. Live sha256:b8266
    4/30/2026, 2:41:24 PM
    Content snapshot 
    {
  "nct_id": "NCT02623699",
  "phase": "phase_3",
  "status": "completed",
  "domain": "als",
  "indication": "SOD1-mutant ALS",
  "intervention": "Tofersen (antisense oligonucleotide targeting SOD1)",
  "sponsor": "Biogen",
  "n_enrolled": 108,
  "primary_endpoint": "ALSFRS-R change at week 28",
  "summary": "Failed primary in VALOR; FDA accelerated approval April 2023 based on plasma neurofilament-light reduction. Surrogate-endpoint case study.",
  "metadata": {}
}