=== PUBMED RESULTS: nlrp3 inhibitors parkinson's disease clinical trials ===
1. PMID:35456966 — Biomarker of Neuroinflammation in Parkinson's Disease.
Int J Mol Sci (2022)
Authors: Liu TW, Chen CM, Chang KH
2. PMID:40792655 — Anti-Neuroinflammatory and Anti-Inflammatory Effects of the NLRP3 Inhibitor NT-0796 in Subjects with Parkinson's Disease.
Mov Disord (2025)
Authors: Clarke N, Thornton P, Reader V
3. PMID:35721113 — The XPO1 Inhibitor KPT-8602 Ameliorates Parkinson's Disease by Inhibiting the NF-κB/NLRP3 Pathway.
Front Pharmacol (2022)
Authors: Liu S, Wang S, Gu R
4. PMID:34739911 — The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease.
J Neuroimmunol (2021)
Authors: Lashgari NA, Roudsari NM, Momtaz S
5. PMID:38860393 — Research progress on phosphodiesterase 4 inhibitors in central nervous system diseases.
Zhejiang Da Xue Xue Bao Yi Xue Ban (2024)
Authors: Adili A, Dilihumaer A, Zhu H
=== CLINICAL TRIALS: gut microbiome parkinson's disease ===
1. NCT03671785 — Study of the Fecal Microbiome in Patients With Parkinson's Disease
Status: COMPLETED, Phase: PHASE1
Conditions: Parkinson Disease
Interventions: PRIM-DJ2727, Placebo oral capsule
2. NCT07443293 — IMPACT 360 for Parkinson's Disease
Status: RECRUITING, Phase: PHASE2
Conditions: Parkinson's Disease (PD), REM Sleep Behavior Disorder
Interventions: Exercise, Meditation, Diet
3. NCT05347407 — Parkinson's Disease Biomarkers in Nerve Cells in the Gut
Status: RECRUITING, Phase: Unknown
Conditions: Parkinson Disease
Interventions: Colonoscopy
4. NCT06118294 — Efficacy of Probiotics for Parkinson Disease (PD)
Status: WITHDRAWN, Phase: NA
Conditions: Parkinson's Disease (PD), Movement Disorders, Depression
Interventions: probiotics, Placebo
5. NCT06596746 — Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
Status: RECRUITING, Phase: Unknown
Conditions: Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies
Interventions: Observation
=== DISEASE INFO: parkinson's disease ===
{
"_id": "MONDO:0000828",
"_score": 8.400046,
"disease_ontology": {
"_license": "https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt",
"ancestors": [
"DOID:863",
"DOID:4",
"DOID:1289",
"DOID:0050890",
"DOID:331",
"DOID:0060894",
"DOID:7",
"DOID:14330"
],
"children": [],
"def": "\"An early-onset Parkinson's disease that is characterized by onset of motor symptoms prior to 21 years of age.\" [url:https\\://www.ncbi.nlm.nih.gov/pubmed/25904081]",
"descendants": [],
"doid": "DOID:0060893",
"name": "juvenile-onset Parkinson's disease",
"parents": [
"DOID:0060894"
],
"synonyms": {
"exact": [
"juvenile-onset Parkinson disease"
]
},
"xrefs": {}
},
"mondo": {
"ancestors": [
"MONDO:0017279",
"MONDO:0021095",
"MONDO:0005180",
"MONDO:0002602",
"MONDO:0005071",
"MONDO:0005560",
"MONDO:0000001",
"MONDO:0003847",
"MONDO:0100545",
"MONDO:0003996",
"MONDO:0700096"
],
"children": [
"MONDO:0011706",
"MONDO:0014231",
"MONDO:0800369"
],
"descendants": [
"MONDO:0017809",
"MONDO:0800369",
"MONDO:0011706",
"MONDO:0014231"
],
"has_characteristic": {
"hp": [
"HP:0003621"
]
},
"has_onset_before": {
"hsapdv": [
"HsapDv:0000114"
]
},
"label": "juvenile-onset Parkinson disease",
"mondo": "MONDO:0000828",
"parents": [
"MONDO:0017279"
],
"synonym": {
"related": [
"juvenile-onset Parkinson's disease"
]
},
"xrefs": {
"doid": [
"DOID:0060893"
],
"gard": [
"0022833"
],
"medgen": [
"155699"
],
"umls": [
"C0752105"
]
}
}
}