Version history

{
  "session_id": "sess_SDA-2026-04-01-gap-20260401-225155",
  "round_number": 3,
  "agent_persona": "persona-tool_execution",
  "agent_backend": "us.anthropic.claude-sonnet-4-20250514",
  "action": "tool_execution",
  "content": "\n=== PUBMED RESULTS: nlrp3 inhibitors parkinson's disease clinical trials ===\n1. PMID:35456966 — Biomarker of Neuroinflammation in Parkinson's Disease.\n   Int J Mol Sci (2022)\n   Authors: Liu TW, Chen CM, Chang KH\n2. PMID:40792655 — Anti-Neuroinflammatory and Anti-Inflammatory Effects of the NLRP3 Inhibitor NT-0796 in Subjects with Parkinson's Disease.\n   Mov Disord (2025)\n   Authors: Clarke N, Thornton P, Reader V\n3. PMID:35721113 — The XPO1 Inhibitor KPT-8602 Ameliorates Parkinson's Disease by Inhibiting the NF-κB/NLRP3 Pathway.\n   Front Pharmacol (2022)\n   Authors: Liu S, Wang S, Gu R\n4. PMID:34739911 — The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease.\n   J Neuroimmunol (2021)\n   Authors: Lashgari NA, Roudsari NM, Momtaz S\n5. PMID:38860393 — Research progress on phosphodiesterase 4 inhibitors in central nervous system diseases.\n   Zhejiang Da Xue Xue Bao Yi Xue Ban (2024)\n   Authors: Adili A, Dilihumaer A, Zhu H\n\n\n=== CLINICAL TRIALS: gut microbiome parkinson's disease ===\n1. NCT03671785 — Study of the Fecal Microbiome in Patients With Parkinson's Disease\n   Status: COMPLETED, Phase: PHASE1\n   Conditions: Parkinson Disease\n   Interventions: PRIM-DJ2727, Placebo oral capsule\n2. NCT07443293 — IMPACT 360 for Parkinson's Disease\n   Status: RECRUITING, Phase: PHASE2\n   Conditions: Parkinson's Disease (PD), REM Sleep Behavior Disorder\n   Interventions: Exercise, Meditation, Diet\n3. NCT05347407 — Parkinson's Disease Biomarkers in Nerve Cells in the Gut\n   Status: RECRUITING, Phase: Unknown\n   Conditions: Parkinson Disease\n   Interventions: Colonoscopy\n4. NCT06118294 — Efficacy of Probiotics for Parkinson Disease (PD)\n   Status: WITHDRAWN, Phase: NA\n   Conditions: Parkinson's Disease (PD), Movement Disorders, Depression\n   Interventions: probiotics, Placebo\n5. NCT06596746 — Neurodegenerative Diseases Progression Markers (MARKERS-NDD)\n   Status: RECRUITING, Phase: Unknown\n   Conditions: Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies\n   Interventions: Observation\n\n\n=== DISEASE INFO: parkinson's disease ===\n{\n  \"_id\": \"MONDO:0000828\",\n  \"_score\": 8.400046,\n  \"disease_ontology\": {\n    \"_license\": \"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt\",\n    \"ancestors\": [\n      \"DOID:863\",\n      \"DOID:4\",\n      \"DOID:1289\",\n      \"DOID:0050890\",\n      \"DOID:331\",\n      \"DOID:0060894\",\n      \"DOID:7\",\n      \"DOID:14330\"\n    ],\n    \"children\": [],\n    \"def\": \"\\\"An early-onset Parkinson's disease that is characterized by onset of motor symptoms prior to 21 years of age.\\\" [url:https\\\\://www.ncbi.nlm.nih.gov/pubmed/25904081]\",\n    \"descendants\": [],\n    \"doid\": \"DOID:0060893\",\n    \"name\": \"juvenile-onset Parkinson's disease\",\n    \"parents\": [\n      \"DOID:0060894\"\n    ],\n    \"synonyms\": {\n      \"exact\": [\n        \"juvenile-onset Parkinson disease\"\n      ]\n    },\n    \"xrefs\": {}\n  },\n  \"mondo\": {\n    \"ancestors\": [\n      \"MONDO:0017279\",\n      \"MONDO:0021095\",\n      \"MONDO:0005180\",\n      \"MONDO:0002602\",\n      \"MONDO:0005071\",\n      \"MONDO:0005560\",\n      \"MONDO:0000001\",\n      \"MONDO:0003847\",\n      \"MONDO:0100545\",\n      \"MONDO:0003996\",\n      \"MONDO:0700096\"\n    ],\n    \"children\": [\n      \"MONDO:0011706\",\n      \"MONDO:0014231\",\n      \"MONDO:0800369\"\n    ],\n    \"descendants\": [\n      \"MONDO:0017809\",\n      \"MONDO:0800369\",\n      \"MONDO:0011706\",\n      \"MONDO:0014231\"\n    ],\n    \"has_characteristic\": {\n      \"hp\": [\n        \"HP:0003621\"\n      ]\n    },\n    \"has_onset_before\": {\n      \"hsapdv\": [\n        \"HsapDv:0000114\"\n      ]\n    },\n    \"label\": \"juvenile-onset Parkinson disease\",\n    \"mondo\": \"MONDO:0000828\",\n    \"parents\": [\n      \"MONDO:0017279\"\n    ],\n    \"synonym\": {\n      \"related\": [\n        \"juvenile-onset Parkinson's disease\"\n      ]\n    },\n    \"xrefs\": {\n      \"doid\": [\n        \"DOID:0060893\"\n      ],\n      \"gard\": [\n        \"0022833\"\n      ],\n      \"medgen\": [\n        \"155699\"\n      ],\n      \"umls\": [\n        \"C0752105\"\n      ]\n    }\n  }\n}\n",
  "tokens_used": "998"
}