# Research Question: Co-Expression Modules in Alzheimer's Disease
## Hypothesis 1: Conserved Synaptic-Mitochondrial Module Across Vulnerable Regions
**Title:** Cross-regional co-expression module integrating synaptic transmission and mitochondrial dysfunction as a unified AD hallmark
**Description:** A WGCNA-derived module containing synaptic vesicle genes (SYN1, SYN2, SYT1) and mitochondrial oxidative phosphorylation components (MT-ND1, MT-CO1, UQCRC1) is consistently upregulated across prefrontal cortex, hippocampus, and entorhinal cortex in AD. This reflects compensatory synaptic hyperactivity paired with mitochondrial stress response—reflect