Version history

{
  "session_id": "sess_SDA-BIOMNI-GENE_COE-55fc5237",
  "round_number": 1,
  "agent_persona": "persona-theorist",
  "agent_backend": "mini-max",
  "action": "propose",
  "content": "\n\n# Research Question: Co-Expression Modules in Alzheimer's Disease\n\n## Hypothesis 1: Conserved Synaptic-Mitochondrial Module Across Vulnerable Regions\n\n**Title:** Cross-regional co-expression module integrating synaptic transmission and mitochondrial dysfunction as a unified AD hallmark\n\n**Description:** A WGCNA-derived module containing synaptic vesicle genes (SYN1, SYN2, SYT1) and mitochondrial oxidative phosphorylation components (MT-ND1, MT-CO1, UQCRC1) is consistently upregulated across prefrontal cortex, hippocampus, and entorhinal cortex in AD. This reflects compensatory synaptic hyperactivity paired with mitochondrial stress response—reflect",
  "tokens_used": "164"
}