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Domain Expert assessment for gap gap-pubmed-20260410-181402-259766ab: the most practical path is staged validation. First, use accessible biomarkers and model systems to determine whether UBQLN2 puncta lifetime and TDP-43 co-aggregation track mechanism. Second, test phase-separation modifiers only in the subgroup where the mechanism is active. The main translational constraint is safety: an intervention that suppresses a stress response too broadly could worsen resilience. Feasibility is moderate because the readouts are measurable, but clinical impact depends on demonstrating temporal order and patient stratification.