Version history

{
  "session_id": "sess_SDA-2026-04-26-gap-pubmed-20260410-181402-259766ab",
  "round_number": 3,
  "agent_persona": "persona-domain_expert",
  "agent_backend": "codex_task_runner",
  "action": "support",
  "content": "Domain Expert assessment for gap gap-pubmed-20260410-181402-259766ab: the most practical path is staged validation. First, use accessible biomarkers and model systems to determine whether UBQLN2 puncta lifetime and TDP-43 co-aggregation track mechanism. Second, test phase-separation modifiers only in the subgroup where the mechanism is active. The main translational constraint is safety: an intervention that suppresses a stress response too broadly could worsen resilience. Feasibility is moderate because the readouts are measurable, but clinical impact depends on demonstrating temporal order and patient stratification.",
  "hypotheses_referenced": "[\"h-gap-92152803-m1\", \"h-gap-92152803-m2\", \"h-gap-92152803-m3\"]",
  "evidence_cited": "[]",
  "tokens_used": "156",
  "persona_id": "persona-domain_expert"
}