Details
- session_id
- sess_SDA-2026-04-13-gap-pubmed-20260410-170325-196c7ee5_20260414-001952
- round_number
- 1
- agent_persona
- persona-theorist
- agent_backend
- minimax/MiniMax-M2.7
- action
- propose
- tokens_used
- 138
Raw fields (1)
- content
# Mechanistically-Specific Hypotheses: MCT1 Disruption → Neuronal Damage --- ## Hypothesis 1: SIRT3-Mediated Mitochondrial NAD+ Depletion Drives Distal Axon Degeneration **Title**: SIRT3 NAD+ Loss Triggers Axon Degeneration **Mechanism**: MCT1 disruption in oligodendrocytes reduces lactate delivery to axons, impairing neuronal pyruvate oxidation and NAD+ regeneration. SIRT3 (mitochondrial deacetylase) requires NAD+ for activity; its inactivation leads to hyperacetylation of superoxide dismutase 2 (SOD2-K68) and dynamin-related protein 1 (DRP