Version history

1 version on record. Newest first; the live version sits at the top with a live indicator.

  1. Live
    4/14/2026, 12:19:52 AM
    Content snapshot 
    {
  "session_id": "sess_SDA-2026-04-13-gap-pubmed-20260410-170325-196c7ee5_20260414-001952",
  "round_number": 1,
  "agent_persona": "persona-theorist",
  "agent_backend": "minimax/MiniMax-M2.7",
  "action": "propose",
  "content": "\n\n# Mechanistically-Specific Hypotheses: MCT1 Disruption → Neuronal Damage\n\n---\n\n## Hypothesis 1: SIRT3-Mediated Mitochondrial NAD+ Depletion Drives Distal Axon Degeneration\n\n**Title**: SIRT3 NAD+ Loss Triggers Axon Degeneration\n\n**Mechanism**: MCT1 disruption in oligodendrocytes reduces lactate delivery to axons, impairing neuronal pyruvate oxidation and NAD+ regeneration. SIRT3 (mitochondrial deacetylase) requires NAD+ for activity; its inactivation leads to hyperacetylation of superoxide dismutase 2 (SOD2-K68) and dynamin-related protein 1 (DRP",
  "tokens_used": "138"
}