No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- APOE2 (Apolipoprotein E2)
APOE2 (Apolipoprotein E2) ## Overview Apoe2 (Apolipoprotein E2) plays an important
Read more → - LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy for APOE4 Homozygote AD
APOE2 Neuroprotection The [APOE2](/entities/apoe2) isoform (encoded by the APOE
Read more → - LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for APOE4 Homozygote AD
APOE2 Neuroprotection The [APOE2](/entities/apoe2) isoform is associated with significantly
Read more → - APOE contributes to Alzheimer's disease by regulating both beta-amyloid deposition
APOE2, APOE3, APOE4) that differ in their effects on amyloid
Read more → - APOE contributes to Alzheimer's disease by regulating both beta-amyloid deposition
APOE2, APOE3, APOE4) that differ in their effects on amyloid
Read more →
Graph neighborhood (30 nodes · 58 edges)
Click a neighbor to navigate · double-click opens in a new tab · open in full graph viewer
Related hypotheses
- APOE Isoform Conversion Therapy
APOE4 allele to the protective APOE3 or APOE2 sequence using base editing or prime editing ... changes Arg→Cys (APOE3→APOE2) APOE4 (Arg112/Arg158) increases AD risk 3-4x per allele
- AAV-Mediated APOE2/APOE3 Gene Delivery to Convert APOE Genotype
Deliver AAV vectors encoding human APOE3 or APOE2 under astrocyte-specific promoters (GFAP, GFA2 ... Neurology 2024). Identifier preclinical-to-clinical. 2. APOE2 is neuroprotecti…
- Microglial Disease-Associated States: TREM2-Independent Pathways Driving Neuroinflammation
silencing in preclinical IND-enabling studies; AAV-APOE2 conversion approach advanced. Identifier ongoing preclinical ... silencing in preclinical IND-enabling studies; AAV-APOE2 …
- APOE4-Selective Lipid Nanoemulsion Therapy
fold in homozygotes compared to the protective APOE2 and neutral APOE3 variants. The APOE protein ... compared to cysteine at position 112 in APOE2 and APOE3. This amino acid subs…
- Interfacial Lipid Mimetics to Disrupt Domain Interaction
terminal (CT) domain. Unlike the protective APOE2 and neutral APOE3 isoforms, APOE4 exhibits a salt ... unique domain-domain interactions not present in APOE2 or APOE3, with the N…