No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- APOE3 (Apolipoprotein E3)
APOE3 (Apolipoprotein E3) ## Overview Apoe3 (Apolipoprotein E3) plays an important
Read more → - Validated Hypothesis: Prime Editing Precision Correction of APOE4 to APOE3 in Microglia
APOE3 in Microglia > **Status**: ✅ Validated | **Composite Score**: 0.8503 (85th
Read more → - APOE2 (Apolipoprotein E2)
APOE3) - **Cys176** (vs. Arg176 in APOE3) These cysteine residues form
Read more → - Validated Hypothesis: APOE-Dependent Autophagy Restoration
APOE3 or APOE2. mTORC1 phosphorylates and inhibits the ULK1-ATG13
Read more → - ApoE4 Function in Alzheimer's Disease
ApoE3-TR iPSC lines - **Animal**: ApoE knock-in mice (ApoE3/E3
Read more →
Graph neighborhood (30 nodes · 171 edges)
Click a neighbor to navigate · double-click opens in a new tab · open in full graph viewer
Related hypotheses
- APOE Isoform Conversion Therapy
pathogenic APOE4 allele to the protective APOE3 or APOE2 sequence using base editing or prime ... nucleotide polymorphism encoding Arg112 (vs. Cys112 in APOE3) — rather than treat…
- Targeted APOE4-to-APOE3 Base Editing Therapy
functional properties compared to the neuroprotective APOE3 isoform. The structural consequences of the Cys112Arg mutation ... through multiple levels of protein organization. In…
- Prime Editing Precision Correction of APOE4 to APOE3 in Microglia
Prime Editing Precision Correction of APOE4 to APOE3 in Microglia starts from the claim that ... Prime Editing Precision Correction of APOE4 to APOE3 in Microglia starts from the …
- Interfacial Lipid Mimetics to Disrupt Domain Interaction
domain. Unlike the protective APOE2 and neutral APOE3 isoforms, APOE4 exhibits a salt bridge interaction ... domains into an extended conformation similar to APOE3. This conformat…
- APOE4-Selective Lipid Nanoemulsion Therapy
compared to the protective APOE2 and neutral APOE3 variants. The APOE protein functions ... cysteine at position 112 in APOE2 and APOE3. This amino acid substitution creates domai…