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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- APP — Amyloid Precursor Protein
APP"] -->|"data in"| APP["APP"] AMYLOID["AMYLOID"] -.->|"inhibits"| APP["APP
Read more → - APP Protein
APP["APP"] APP["APP"] -->|"causes"| EOAD["EOAD"] APP["APP"] -->|"causes
Read more → - Amyloid Precursor Protein (APP)
APP](/proteins/app) - Small molecules affecting [APP](/proteins/app) trafficking - [APP](/proteins/app
Read more → - APP Gene Dosage Reduction Therapy for Down Syndrome
APP["APP"] APP["APP"] -->|"causes"| EOAD["EOAD"] APP["APP"] -->|"causes
Read more → - Familial Alzheimer's Disease Genetics
APP["APP"] -->|"therapeutic target"| Als["Als"] APP["APP"] -->|"activates"| Als["Als"] APP
Read more →
Graph neighborhood (30 nodes · 43 edges)
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Related hypotheses
- Selective Cholinergic Protection via APP Pathway Modulation
Mechanistic Overview Selective Cholinergic Protection via APP Pathway Modulation starts from the claim that modulating ... APP within the disease context of neurodegeneration can …
- Palmitoylation-Targeted BACE1 Trafficking Disruptors
localizes with its substrate, amyloid precursor protein (APP), leading to enhanced amyloidogenic processing. The molecular ... centers on the differential subcellular distribution…
- Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbates Amyloid Pathology
impaired regulatory control of amyloid precursor protein (APP) processing proposes a self-amplifying feedforward loop ... Mechanism of Action ### Cholinergic Modulation of APP Pro…
- Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Partially Irreversible
pathway disruption and cholinergic neurodegeneration. [PMID:40514243] APP-βCTF generated by BACE1 has been directly ... f57f17,color:#000 ``` --- ## Molecular and Cellular Ratio…
- Multi-Modal CRISPR Platform for Simultaneous Editing and Monitoring
phosphorylation state or aggregation propensity. The APP gene, whose duplication causes early-onset Alzheimer ... familial Alzheimer's disease caused by APP duplication, deletion …