No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- ATF4 Gene
ATF4 -->|"activates"| XBP1 ATF4 -->|"activates"| HSPA5 ATF4 -->|"activates"| DDIT3 ATF4
Read more → - ATF4 Protein
ATF4["ATF4 Protein"] -->|"implicated in"| neurodegeneration["neurodegeneration"] ATF4["ATF4 Protein
Read more → - Activating Transcription Factor 4 (ATF4)
ATF4) --- Activating Transcription Factor 4 (ATF4) Gene [ATF4](/genes/atf4) UniProt
Read more → - Integrated Stress Response in Alzheimer's Disease
ATF4 selective modulators**: Compounds that promote ATF4's adaptive functions
Read more → - Mitochondrial Unfolded Protein Response in Neurodegeneration
ATF4: - SIRT1 deacetylates ATF4 enhancing its activity - Resveratrol activates SIRT1
Read more →
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Related hypotheses
- Critical Period Hypothesis: The Therapeutic Window Closes When Neuronal Homeostasis is Irreversibly Disrupted
tau231), activating transcription factor 4 (ATF4), and mitochondrial translocase TOMM40. NfL, a cytoskeletal protein predominantly ... cytoskeletal destabilization and impaired ax…
- Neuronal Integrated Stress Response Modulation
transcripts containing upstream open reading frames, including ATF4 and CHOP. The EIF2B complex, functioning ... disproportionate upregulation of ISR target genes including ATF4, …
- Proteostasis Enhancement via APOE Chaperone Targeting
stress markers (increased XBP1 splicing, ATF4 upregulation, CHOP induction), chaperone depletion (reduced free HSP70 levels ... markers, while UPR activation markers (phospho-eIF2…
- ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degeneration in Alzheimer's Disease
becomes pathologically upregulated through NF-κB and ATF4 transcriptional pathways, leading to excessive accumulation ... through targeted inhibition of NF-κB or ATF4 signaling pa…
- ATF4-DDIT3 stress signaling indirectly represses MAPT transcription during proteostatic stress
Integrated stress response factors redirect