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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- TF
Chronic_Cerebral_Hypoperfusion["Chronic Cerebral Hypoperfusion"] -->|"upregulates"| TF["TF"] MYC["MYC"] -.->|"inhibits
Read more → - FPN1 (Ferroportin)
Chronic_cerebral_hypoperfusion["Chronic cerebral hypoperfusion"] -.->|"downregulates"| FPN1["FPN1"] ACSL4
Read more → - TFRC
Chronic_cerebral_hypoperfusion["Chronic cerebral hypoperfusion"] -->|"upregulates"| TFRC["TFRC"] h_959a4677
Read more → - Ferroportin (SLC40A1)
Chronic_Cerebral_Hypoperfusion["Chronic Cerebral Hypoperfusion"] ferroportin["ferroportin"] -->|"transports"| Portal
Read more → - Vascular Dementia Mechanisms — Overlap with Alzheimer's Disease
Chronic Cerebral Hypoperfusion ### Hemodynamic Mechanisms Chronic cerebral hypoperfusion (CCH) is the central
Read more →
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Related hypotheses
- Vascular mural cell degeneration precedes and exacerbates parenchymal pathology
neuronal amyloid-beta production rates. ### Cerebral Hypoperfusion, Chronic Ischemia, and Tau Pathology Smooth muscle cell ... loss of neurovascular coupling, produces chronic ce…
- BMP4 Pathway Inhibition for Oligodendrocyte Myelination Support
oligodendrocyte differentiation and myelin production. However, chronic cerebral hypoperfusion fundamentally disrupts this delicate equilibrium through ... conditions. ## Preclini…
- Vascular-Glial Interface Restoration
These contractile elements enable pericytes to modulate cerebral blood flow at the capillary level, responding ... disrupts this neurovascular coupling, resulting in chronic hypop…
- Cerebral VSMC foam cells induce pericyte detachment via PDGF-BB/VEGF imbalance, impairing neurovascular coupling
following mechanistic claim: Lipid-laden (foam cell) cerebral VSMCs downregulate PDGF-BB secretion (critical ... directly impairing neurovascular coupling and causing chronic hypo…
- Pharmacological P2RY12 inhibition (ticagrelor/clopidogrel) as repurposing probe for neurovascular outcomes
diagnosis. Patients with more than 10 cerebral microbleeds or evidence of cortical superficial siderosis represent ... P301S mice, α-synuclein transgenic models, chronic hypoperfu…