No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- CLU — Clusterin (Apolipoprotein J)
CLU["clu"] -->|"implicated in"| neurodegeneration["neurodegeneration"] CLU["clu"] -->|"activates"| mitophagy
Read more → - Validated Hypothesis: CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-Specific Vulnerability Thresholds
CLU](https://www.ncbi.nlm.nih.gov/gene/?term=APOE, CLU) - [UniProt: APOE, CLU](https://www.uniprot.org
Read more → - Clusterin (CLU / Apolipoprotein J)
CLU["CLU"] -->|"activates"| CLUSTERIN["CLUSTERIN"] CLU["CLU"] -->|"therapeutic target"| CLUSTERIN
Read more → - CLU-Clusterin Amyloid Clearance Dysfunction AD Causal Chain
CLU-Fc | | Gene therapy | AAV-CLU overexpression | Preclinical | AAV9-CLU
Read more → - Clusterin Protein
CLU](https://www.genecards.org/cgi-bin/carddisp.pl?gene=CLU) - [OMIM: CLU](https://www.omim.org/entry/185430) - [IGAP
Read more →
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Related hypotheses
- CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-Specific Vulnerability Thresholds
starts from the claim that modulating APOE, CLU within the disease context of neurodegeneration ... protein aggregation and clearance. Among these, clusterin (CLU) and apolipoprot…
- CLU-APOE-TREM2 Tripartite Axis as a Coordinate Therapeutic Target
Mechanistic Overview CLU-APOE-TREM2 Tripartite Axis as a Coordinate Therapeutic Target starts from ... claim that modulating CLU-APOE-TREM2 axis (LXR/RXR pathway) within the disea…
- Hippocampus ages transcriptionally faster than cerebellum, defining a regional vulnerability axis conserved across species
species starts from the claim that modulating CLU within the disease context of Alzheimer ... species starts from the claim that modulating CLU within the disease context of Alzhe…