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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Complement Activation in Corticobasal Degeneration
complement activation - **Correlation with pathology**: Complement activation markers correlated with
Read more → - Complement System in Neurodegeneration
activate complement through the alternative pathway, and complement activation products
Read more → - Complement System
Complement activation may amplify tau spreading by promoting microglial activation
Read more → - complement-c1q-inhibitor-therapy
COMPLEMENT"] -->|"activates"| Als["Als"] COMPLEMENT["COMPLEMENT"] -->|"activates"| Complement["Complement"] COMPLEMENT
Read more → - Complement Component 3 (C3)
COMPLEMENT"] -->|"activates"| Als["Als"] COMPLEMENT["COMPLEMENT"] -->|"activates"| Complement["Complement"] COMPLEMENT
Read more →
Graph neighborhood (27 nodes · 37 edges)
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Related hypotheses
- Direct C1q Binding Enables FcγR-Independent Complement Activation on Tumor Cells
Direct C1q Binding Enables FcγR-Independent Complement Activation on Tumor Cells starts from the claim ... Direct C1q Binding Enables FcγR-Independent Complement Activation on Tum…
- Astrocyte-Selective APOE4 Silencing via Lipid Nanoparticles
deposition. Critically, astrocytic APOE4 promotes aberrant complement activation through multiple mechanisms. The structural instability ... APOE4 reduces its ability to inhibit …
- Microglial TREM2-Complement Axis Modulation
association and downstream signaling efficiency. Excessive complement activation occurs through multiple pathways in neurodegeneration. Amyloid ... downregulated on vulnerable ne…
- Synaptic Pruning Precision Therapy
disease, α-synuclein pathology similarly triggers complement activation and alters fractalkine signaling, contributing to dopaminergic ... actively phagocytose synapses in respons…
- H2: Perforant Path Synapse Loss via Early Complement Cascade Activation
mechanistic chain from tau oligomers to complement activation is underspecified, and C1q deposition is observed ... Soluble tau oligomers directly activate complement in early AD …