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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- CR1 Gene — Complement Component 1q Receptor
CR1["ad_genetic_risk_loci:CR1"] -->|"data in"| CR1["CR1
Read more → - CR1→Complement Activation→Synaptic Pruning→AD Causal Chain
CR1→Complement Activation→Synaptic Pruning→AD Causal Chain ## Overview The **CR1
Read more → - CR1 Protein
CR1 Protein ## Introduction Cr1 Protein is an important component in the neurobiology
Read more → - PICALM — Phosphatidylinositol Binding Clathrin Assembly Protein
CR1["CR1"] TAU["TAU"] MICROGLIA["Microglia"] PHAGOCYTOSIS["Phagocytosis"] ENDOSOMES["Endosomes
Read more → - Complement System
CR1 (Complement Receptor 1) - CR1 is an AD risk gene
Read more →
Graph neighborhood (30 nodes · 112 edges)
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Related hypotheses
- Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuron Protection
loss during memory impairment. [PMID:27337340]. 5. CR1 implicated in complement receptor in AD genetic ... loss during memory impairment. [PMID:27337340]. 5. CR1 implicated in com…
- SASP-Mediated Complement Cascade Amplification
oxidative damage abundant in AD - **Complement receptors**: CR1, CR3 on synaptic structures - **Aβ oligomers**: Bound ... with 78% accuracy **Genetic Risk** - CR1 variants (rs6656…
- ITGAM/CD11b direct binding explains microglial phagocytosis blockade
complement regulatory gene variants, including CFH and CR1 polymorphisms associated with increased complement activity, could
- Peripheral-Central Immune Decoupling Therapy
contribution to AD — GWAS hits include Trem2, Cr1, and INPP5D, all involved in immune cell
- Heterogeneous astrocyte activation states differentially impact neuronal survival across AD progression
complement receptors on microglial cells (CR3, CR1), driving microglial-mediated pruning of synapses