No definition recorded for this entity.
Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- ITGAM Gene
CD11b), the alpha chain of the heterodimeric receptor alphaMbeta2 (CR3/Mac-1
Read more → - iPSC-Derived Microglia
CD11b** (ITGAM) High **CD45** (PTPRC) Variable **CD68** Inducible **Iba1** (AIF1
Read more → - Microglia in Alzheimer's Disease Neurodegeneration
CD11b. Upon encountering danger-associated molecular patterns (DAMPs) or pathogen
Read more → - Complement Activation in Corticobasal Degeneration
CD11b (CR3 α-chain) antibodies in development - Target microglial phagocytosis
Read more → - Validated Hypothesis: Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuroinflammation in ALS/FTD
CD11b or P2Y12 receptor agonists) could enhance CNS penetration and cellular
Read more →
Graph neighborhood (3 nodes · 3 edges)
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Related hypotheses
- Surface Exposure of SENP1-β1 Integrin Complex Enables Targeted Senolytic Elimination
that modulating SENP1, ITGB1 (β1 integrin), ITGAM (CD11b) within the disease context of neurodegeneration ... that modulating SENP1, ITGB1 (β1 integrin), ITGAM (CD11b) within the …
- ITGAM/CD11b direct binding explains microglial phagocytosis blockade
critical heterodimeric integrin receptor composed of CD11b (ITGAM) and CD18 (ITGB2) subunits. CR3 functions ... includes an N-terminal I-domain within CD11b that contains the prim…
- PINK1/PARK2-Mediated Mitophagy Enhancement for Neuroinflammation Control
that enhanced mitophagy reduced the proportion of CD11b+/CD86+ pro-inflammatory microglia while increasing CD11b
- AAV-PHP.eB-Mediated Microglial IGFBPL1 Expression
brain homogenates confirmed selective targeting to CD11b+/CD45low microglia with minimal expression in CD11b+/CD45high
- LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability in Disease-Associated Microglia
free regions. Lipidomics analysis of FACS-sorted CD11b+ microglia from 6-month-old 5xFAD mice