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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- GJA1 Protein
Connexin-43, Cx43) is the most abundant connexin in the brain
Read more → - GJA1
Connexin-43 Upregulation Enha... Astroglial Gap Junction Coordination via... CX43
Read more → - Validated Hypothesis: Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance
connexin-43 and connexin-30 gap junctions between astrocytes, creating
Read more → - Median Eminence Tanycytes
connexin-43, and they are increasingly recognized as active participants
Read more → - Astrocytic Mitochondrial Transfer + Metabolic Copacking
Connexin-43) gap junction agonists**: Promote gap junction formation for intercellular
Read more →
Graph neighborhood (9 nodes · 9 edges)
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Related hypotheses
- Blocking Astrocyte-Mediated Tau Re-Spreading via Cx43 Hemichannel Inhibition
from the claim that modulating GJA1 (Connexin-43) within the disease context of neuroscience ... from the claim that modulating GJA1 (Connexin-43) within the disease context of ne…
- CX43 hemichannel engineering enables size-selective mitochondrial transfer
proposed therapeutic approach centers on engineering connexin-43 (Cx43) hemichannels, encoded by the GJA1 gene ... conduits for mitochondrial transfer between cells. Connexin-43 f…
- Astroglial Gap Junction Coordination via Connexin-43 Phosphorylation Modulation
Overview Astroglial Gap Junction Coordination via Connexin-43 Phosphorylation Modulation starts from the claim that ... reads: "## **Molecular Mechanism and Rationale** The connex…
- Context-Dependent Cx43 Modulation Based on Disease Stage
Targeting Therapeutics The emerging understanding of Connexin-43 (Cx43) biology in neurodegenerative and neuroinflammatory contexts ... dependent` and the pathway label is `Connex…
- Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance
stores. These calcium transients propagate through connexin-43 and connexin-30 gap junctions between astrocytes ... these models reveals upregulation of AQP4, connexin-43, and gly…
Related debates
- What is the relative contribution of connexin-43 gap junctions vs tunneling nanotubes to mitochondrial transfer?
debate revealed conflicting evidence about whether connexin-43 mediates mitochondrial transfer through gap junctions