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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Short Chain Fatty Acids in Neurodegeneration
GPR41)**: Receptor for propionate and butyrate, expressed in sympathetic ganglia
Read more → - DRP1 (Dynamin-Related Protein 1)
GPR41(["GPR41"]) ginsenoside_Re{"ginsenoside Re"} Zuo_Gui_Wan{"Zuo Gui Wan"} HSF1
Read more → - Section 182: Microbiome Metabolomics and SCFA Therapy in CBS/PSP
GPR41 (FFAR3) Propionate > acetate > butyrate GPR43 (FFAR2) Acetate = propionate > butyrate
Read more → - Short-Chain Fatty Acid Therapy for Neurodegenerative Diseases
GPR41)**: Present in enteric nervous system - **GPR109A**: Anti-inflammatory in macrophages
Read more → - gut-brain-axis-tauopathy
GPR41, GPR43, GPR109A)[@stilling2023]. In the [brain](/brain-regions), butyrate can modulate
Read more →
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Related hypotheses
- Dissociating SCFA's Dual Signaling Through GPR43/GPR41 Biased Agonism
relevant process. The original description reads: "# Engineering GPR41-Biased SCFA Analogs to Bypass GPR43-NLRP3 ... more commonly designated GPR43 (FFAR2) and GPR41 (FFAR3), resp…
- SCFA-Producing Bacterial Depletion → Loss of Neuroprotective Microenvironment
interaction with specific G-protein coupled receptors GPR41 (FFAR3) and GPR43 (FFAR2), which are highly
- SCFA Deficiency Drives Microglial Hyperactivation via GPR43/NF-κB Dysregulation
Gut dysbiosis depletes butyrate-producing
- H7: Enteric Nervous System Alpha-Synuclein Propagation Blocker via Gut Barrier Restoration
activation of G-protein coupled receptors (GPR41, GPR43, GPR109A). At the molecular level, butyrate-mediated
- Microbiota-Microglia Axis Modulation
fatty acid receptors FFAR2 (GPR43) and FFAR3 (GPR41) expressed on microglia. Upon binding, these GPCRs