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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- GPX4 (Glutathione Peroxidase 4)
GPX4["GPX4"] SLC7A11["SLC7A11"] -->|"regulates"| GPX4["GPX4"] GPX4["GPX4"] -.->|"inhibits
Read more → - GPX4 Gene - Glutathione Peroxidase 4
GPX4 GSH -->|"cofactor"| GPX4 GPX4 -->|"inhibits"| FERROPTOSIS GPX4 -->|"maintains"| REDOX
Read more → - Validated Hypothesis: Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Prevents the Self-Amplifying Iron-Ferroptosis-Edema Cascade Post-Cardiac Arrest
GPX4 activity. Simultaneously, oxidative stress directly damages GPX4 protein structure
Read more → - Ferroptosis in Alzheimer's Disease
GPX4) pathway is the central antioxidant system preventing ferroptosis. **GPX4
Read more → - Validated Hypothesis: SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endothelial Ferroptosis After Cardiac Arrest
GPX4](https://www.ncbi.nlm.nih.gov/gene/?term=SLC7A11 (system Xc-) and GPX4) - [UniProt: SLC7A11
Read more →
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Related hypotheses
- GPX4 Selenopeptide Mimetics as Neuroprotective Ferroptosis Blockade
Mechanistic Overview GPX4 Selenopeptide Mimetics as Neuroprotective Ferroptosis Blockade starts from the claim that modulating ... GPX4 within the disease context of neurodegenera…
- Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Prevents the Self-Amplifying Iron-Ferroptosis-Edema Cascade Post-Cardiac Arrest
Mechanistic Overview Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Prevents the Self-Amplifying Iron ... modulating Labile iron pool (deferoxamine t…
- Ferroptosis Inhibition for α-Synuclein Neuroprotection
around the depletion of glutathione peroxidase 4 (GPX4), the sole enzyme capable of reducing phospholipid ... hydroperoxides directly within cellular membranes. GPX4 functions as …
- SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endothelial Ferroptosis After Cardiac Arrest
claim that modulating SLC7A11 (system Xc-) and GPX4 within the disease context of neurodegeneration ... claim that modulating SLC7A11 (system Xc-) and GPX4 within the disease cont…
- SIRT1 Activation Couples Mitochondrial Biogenesis to Ferroptosis Suppression via PGC1alpha-Dependent GPX4 Upregulation in Post-CA Brain
Biogenesis to Ferroptosis Suppression via PGC1alpha-Dependent GPX4 Upregulation in Post-CA Brain starts from ... Biogenesis to Ferroptosis Suppression via PGC1alpha-Dependent GPX4…