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Wiki pages (5)
SciDEX wiki entries that cover this entity. Different pages may focus on the gene, protein, or disease aspects of the same canonical id.
- Hypoxia Neuroprotection in Sporadic Parkinson's Disease
HIF1α or HIF2α) and a constitutively expressed beta subunit (HIF1β
Read more → - Validated Hypothesis: TREM2 R47H Variant-Driven Metabolic Dysfunction as the Primary Trigger for Failed DAM Transition
HIF1α stabilization, which are essential for initiating the glycolytic switch
Read more → - SPAM1-SIRT6 Positive Allosteric Modulator in Neurodegeneration
HIF1α | Deacetylation | Metabolic reprogramming | | PGC-1α | Deacetylation | Mitochondrial biogenesis | ### SIRT6
Read more → - SENP1 — SUMO Specific Peptidase 1
HIF1α under hypoxia. *Cell*. 2007;131(3):584-595. [PMID
Read more → - ARNT - Aryl Hydrocarbon Receptor Nuclear Translocator
HIF1α, HIF2α, AHR, and CLOCK. ## Pathway Diagram ```mermaid flowchart TD ARNT
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Graph neighborhood (11 nodes · 12 edges)
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Related hypotheses
- Microglial Metabolic Trained Immunity via mTOR-HIF1α Axis
mTOR) and hypoxia-inducible factor 1-alpha (HIF1α) signaling axis. Upon exposure to pathogen-associated ... activated mTORC1 complex subsequently phosphorylates and stabilizes HIF…
- Metabolic Rewiring via SPP1-Induced HIF1α Glycolytic Shift
Rationale** The SPP1 (secreted phosphoprotein 1, osteopontin)-HIF1α metabolic rewiring pathway represents a sophisticated cellular ... Critically, mTORC1 also directly phosphoryl…
- Dose-Response Framework: PINK1/Parkin Mitophagy as the Critical Mediator Linking HBOT Parameters to Tau Clearance
activation involve hypoxia-inducible factor 1-alpha (HIF1α) and cystatin C, both of which ... modulated by HBOT preconditioning. HIF1α functions as a master regulator of cellular …
- TREM2-Mediated Microglial Metabolic Reprogramming Accelerates Tau Pathological Spread
oxidative phosphorylation to glycolysis through dysregulated mTOR-HIF1α pathways. This metabolic switch fundamentally alters microglial ... pathway label is `TREM2/DAP12 signaling…
- Dysregulated microglial glycolysis via HIF1α activation shifts the balance from neuroprotective surveillance to complement-mediated synapse engulfment
Mechanistic Overview Dysregulated microglial glycolysis via HIF1α activation shifts the balance from neuroprotective surveillance ... reads: "## Mechanistic Overview Dysregulated …